Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin.
- S. Vujcic, P. Diegelman, C. Bacchi, D. Kramer, C. Porter
- Biology, Computer ScienceBiochemical Journal
- 1 November 2002
The data indicate that the enzyme represents a novel mammalian oxidase which, on the basis of substrate specificity, is designated spermine oxidase in order to distinguish it from the PAO involved in polyamine back-conversion.
SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis
The biological and pharmacokinetic properties of SCYX-7158 suggest that this compound will be efficacious and safe to treat stage 2 HAT, and is selected to enter preclinical studies, with expected progression to phase 1 clinical trials in 2011.
Polyamine metabolism: a potential therapeutic target in trypanosomes.
- C. Bacchi, H. Nathan, S. Hutner, P. McCann, A. Sjoerdsma
- Biology, ChemistryScience
- 17 October 1980
alpha-Difluoromethylornithine (RMI 71,782), a specific irreversible inhibitor of the first step in polyamine biosynthesis, cures mice infected with a virulent, rodent-passaged strain of Trypanosoma brucei bruceo, drawing attention to polyamine metabolism as a target for chemotherapy of parasitic diseases.
In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei.
- A. Fairlamb, G. Henderson, C. Bacchi, A. Cerami
- Biology, ChemistryMolecular and biochemical parasitology (Print)
- 1 June 1987
Inducible Resistance to Oxidant Stress in the Protozoan Leishmania chagasi *
- Melissa A. Miller, S. McGowan, Mary E. Wilson
- BiologyJournal of Biological Chemistry
- 27 October 2000
It is concluded that leishmania have redundant mechanisms for resisting toxic oxidants, some are induced during developmental change and others are induced in response to environmental stress.
Effect of DL-alpha-difluoromethylornithine on polyamine synthesis and interconversion in Trichomonas vaginalis grown in a semi-defined medium.
- N. Yarlett, C. Bacchi
- BiologyMolecular and biochemical parasitology (Print)
- 1 October 1988
Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis.
- R. Jacobs, J. Plattner, R. Don
- BiologyFuture Medicinal Chemistry
- 22 August 2011
A series of benzoxaborole-6-carboxamides is discovered and optimized to provide trypanocidal compounds that are orally active in murine models of human African trypanosomiasis and the in vivo pharmacokinetic properties of lead compounds from the series are reported.
Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity.
- X. Bi, Christina Lopez, C. Bacchi, D. Rattendi, P. Woster
- Chemistry, BiologyBioorganic & Medicinal Chemistry Letters
- 15 June 2006
Subcellular Localization of the Enzymes of the Arginine Dihydrolase Pathway in Trichomonas vaginalis and Tritrichomonas foetus
- NIGEL YARLETT, DONALD G. LINDMARK, B. Goldberg, M. Moharrami, C. Bacchi
- Biology, Computer ScienceJournal of Eukaryotic Microbiology
- 1 November 1994
The results demonstrate the presence of theArginine dihydrolase pathway in T. foetus and indicate that at least a portion of the arginine deiminase in trichomonads is membrane associated.
Chemotherapy of Human African Trypanosomiasis
- C. Bacchi
- MedicineInterdisciplinary Perspectives on Infectious…
- 20 August 2009
This article presents an update of classic chemotherapeutic agents, in use for >50 years and the recent development of promising non-toxic combination chemotherapy suitable for use in rural clinics.