• Publications
  • Influence
Chemotherapy-induced resistance by ATP-binding cassette transporter genes.
TLDR
This review emphasizes the involvement of ABC transporters in resistance to chemotherapy, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABCtransporters. Expand
Modulation of human BCRP (ABCG2) activity by anti-HIV drugs.
TLDR
It is suggested that inhibition of BCRP might contribute to drug-drug interactions observed during HAART in vivo and possibly also the superior effectiveness of combination antiretroviral therapy. Expand
Antimicrobial activity of clove and rosemary essential oils alone and in combination
TLDR
The time‐kill curves of clove and rosemary essential oils towards three strains showed clearly bactericidal and fungicidal processes of 1/2 × MIC, MIC, MBC and 2 × MIC. Expand
From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy.
  • T. Efferth
  • Biology, Medicine
  • Seminars in cancer biology
  • 28 February 2017
TLDR
A systematic overview of the literature published over the past two decades until the end of 2016 on artemisinin (ARS), which has been developed as antimalarial drug and is used worldwide, finds that ARS-type drugs also reveal anticancer in vitro and in vivo. Expand
Activities of Ten Essential Oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 Cancer Cells
TLDR
Thyme, cinnamon, rose, and lavender essential oils exhibited the best antibacterial activities towards P. acnes and in vitro toxicology against three human cancer cell lines and the cytotoxicity of 10 essential oils on human prostate carcinoma cell (PC-3) was significantly stronger than on human lung carcinoma (A549) and human breast cancer (MCF-7) cell lines. Expand
Cameroonian Medicinal Plants: Pharmacology and Derived Natural Products
TLDR
In conclusion, many medicinal plants traditionally used in Cameroon to treat various ailments displayed good activities in vitro, explaining the endeavor of Cameroonian research institutes in drug discovery from indigenous medicinal plants. Expand
Molecular modes of action of artesunate in tumor cell lines.
TLDR
A profound cytotoxic action of the antimalarial, artesunate (ART), was identified against 55 cancer cell lines of the U.S. National Cancer Institute (NCI) and 3 of the 12 genes were used to prove a causative relationship. Expand
The role of p53 in cancer drug resistance and targeted chemotherapy
TLDR
Small molecules that restore the wild-type conformation of p53 and, consequently, rebuild its proper function have been identified and their potential as cancer chemotherapeutics are analyzed. Expand
Molecular principles of cancer invasion and metastasis (review).
TLDR
Some of the molecular principles which underlie the metamorphosis of a normal tissue cell into an invasive cancer cell are described as well as some aspects of current research are covered. Expand
Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells.
  • T. Efferth
  • Biology, Medicine
  • Current drug targets
  • 31 March 2006
TLDR
The present review focuses on the mechanisms of action of artemisinins in cancer cells relating to: anti-proliferative and anti-angiogenic effects, induction of apoptosis, oxidative stress, and multidrug resistance. Expand
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