S-Adenosylmethionine

Known as: S-(5'-Deoxyadenosin-5'-yl)-L-methionine, SAMe, 5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine Hydroxide, Inner Salt 
A nutritional supplement that is synthesized from adenosine triphosphate (ATP) and the amino acid methionine by the endogenous essential enzyme… (More)
National Institutes of Health

Related topics

Related topics

22 relations

Broader (4)

AdenosineAmino Acids, SulfurMethioninehigh energy compound

Narrower (9)

AdoEnYnFO-1561GumbaralS Amet
(More)
In BloodMAT1A geneagonistsanalogs & derivatives
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Radical S-Adenosylmethionine Enzymes
ing a H-atom from substrate. These and other kinetics studies demonstrated that PFL-AE could undergo multiple turnover events… (More)
Is this relevant?
Highly Cited
2013
Highly Cited
2013
Influence of threonine metabolism on S-adenosylmethionine and histone methylation.
Threonine is the only amino acid critically required for the pluripotency of mouse embryonic stem cells (mESCs), but the detailed… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.
BACKGROUND Autism is a complex neurodevelopmental disorder that usually presents in early childhood and that is thought to be… (More)
  • figure 1
  • table 1
  • table 2
Is this relevant?
Review
2002
Review
2002
SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold.
The S-adenosylmethionine-dependent methyltransferase enzymes share little sequence identity, but incorporate a highly conserved… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases.
Asymmetrical dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor. It is formed by protein arginine N… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 2
  • figure 7
Is this relevant?
Review
1997
Review
1997
S-adenosylmethionine synthesis: molecular mechanisms and clinical implications.
Methionine adenosyltransferase (MAT) is an ubiquitous enzyme that catalyzes the synthesis of S-adenosylmethionine from methionine… (More)
Is this relevant?
Review
1996
Review
1996
S-Adenosylmethionine and methylation.
S-Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease.
S-Adenosylmethionine is an essential ubiquitous metabolite central to many biochemical pathways, including transmethylation and… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes.
Three regions of sequence similarity have been reported in several protein and small-molecule S-adenosylmethionine-dependent… (More)
Is this relevant?
Review
1992
Review
1992
The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine.
A unified, biochemical hypothesis is proposed to explain the pathogenesis of homocysteinemia. This hypothesis is based on the… (More)
  • figure 1
  • table 1
  • figure 2
Is this relevant?