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Rz967

Known as: hammerhead ribozyme Rz967 
National Institutes of Health

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1 relation

Broader (1)

Catalytic RNA

Papers overview

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Highly Cited
2007
Highly Cited
2007
Endogenous bone morphogenetic protein-7 controls the motility of prostate cancer cells through regulation of bone morphogenetic protein antagonists.
Highly Cited
2002
Highly Cited
2002
A pH-dependent conformational change, rather than the chemical step, appears to be rate-limiting in the hammerhead ribozyme cleavage reaction.
We have investigated the chemical basis for a previously observed 7.8 A conformational change in the hammerhead ribozyme that… 
Highly Cited
2002
Highly Cited
2002
Modulation of the atypical multidrug-resistant phenotype by a hammerhead ribozyme directed against the ABC transporter BCRP/MXR/ABCG2
The phenomenon of multidrug resistance (MDR) in human cancers is one of the major causes of failure of chemotherapy. A recently… 
Highly Cited
2001
Highly Cited
2001
Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase.
Telomerase activity is necessary and sufficient for immortality in many cells and hence represents a prime target for antitumor… 
2001
2001
Functional disruption of IEX‐1 expression by concatemeric hammerhead ribozymes alters growth properties of 293 cells
Highly Cited
1997
Highly Cited
1997
Development of a hammerhead ribozyme against bcl‐2. I. Preliminary evaluation of a potential gene therapeutic agent for hormone‐refractory human prostate cancer
The bcl‐2 oncoprotein suppresses apoptosis and, when overexpressed in prostate cancer cells, makes these cells resistant to a… 
Highly Cited
1997
Highly Cited
1997
The subcellular localization and length of hammerhead ribozymes determine efficacy in human cells.
The length requirements of the antisense portion of hammerhead ribozymes for efficacy in living cells was investigated. The HIV… 
Highly Cited
1997
Highly Cited
1997
Hammerhead ribozymes with a faster cleavage rate.
A hammerhead ribozyme that was previously reported to have a rate of chemical cleavage 10-fold faster than that of conventional… 
Highly Cited
1996
Highly Cited
1996
Rescue of abasic hammerhead ribozymes by exogenous addition of specific bases.
We have synthesized 13 hammerhead ribozyme variants, each containing an abasic residue at a specific position of the catalytic… 
Highly Cited
1996
Highly Cited
1996
The ion-induced folding of the hammerhead ribozyme: core sequence changes that perturb folding into the active conformation.
The hammerhead ribozyme undergoes an ion-dependent folding process into the active conformation. We find that the folding can be… 
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