Roflumilast

Known as: 3-Cyclopropylmethoxy-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide, 3-cyclopropylmethoxy-4-difluoromethoxy-N-(3,5-di-chloropyrid-4-yl)benzamide, ROF 
An orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activities… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2011
Highly Cited
2011
BACKGROUND As chronic obstructive pulmonary disease (COPD) is a heterogeneous disease it is unlikely that all patients will… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND The phosphodiesterase-4 inhibitor roflumilast can improve lung function and prevent exacerbations in certain patients… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Patients with chronic obstructive pulmonary disease (COPD) have few options for treatment. The efficacy and safety of… (More)
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Highly Cited
2007
Highly Cited
2007
RATIONALE The oral phosphodiesterase-4 (PDE4) inhibitor, roflumilast, can improve lung function in moderate chronic obstructive… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Roflumilast is a targeted oral once-daily administered phosphodiesterase 4 (PDE4) inhibitor with clinical efficacy in… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Chronic obstructive pulmonary disease (COPD) is characterised by progressive airflow limitation associated with… (More)
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Highly Cited
2005
Highly Cited
2005
RATIONALE There is a need for new agents capable of suppressing the inflammatory response in chronic obstructive pulmonary… (More)
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Highly Cited
2002
Highly Cited
2002
Abstract. In this paper, we propose a new model for image restoration and image decomposition into cartoon and texture, based on… (More)
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Highly Cited
2001
Highly Cited
2001
From a series of benzamide derivatives, roflumilast (3-cyclo-propylmethoxy-4-difluoromethoxy-N-[3,5-di-chloropyrid-4-yl… (More)
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