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Ribonucleoside-diphosphate reductase

Known as: Ribonucleoside Diphosphate Reductase, Reductase, Ribonucleoside Diphosphate, Diphosphate Reductase, Ribonucleoside 
An enzyme of the oxidoreductase class that catalyzes the formation of 2'-deoxyribonucleotides from the corresponding ribonucleotides using NADPH as… Expand
National Institutes of Health

Related topics

Related topics

11 relations
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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Narrower (3)

NrdI protein, Mycoplasma gallisepticumRnr4 protein, S cerevisiaeribonucleotide reductase M2

Broader (1)

Ribonucleotide Reductase

Papers overview

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Highly Cited
2011
Highly Cited
2011
Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I
An enzyme that removes supercoils from DNA can cause mutations when RNA bases accidentally get incorporated into the DNA. The… Expand
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Highly Cited
2007
Highly Cited
2007
The 90S Preribosome Is a Multimodular Structure That Is Assembled through a Hierarchical Mechanism
ABSTRACT The 90S preribosomal particle is required for the production of the 18S rRNA from a pre-rRNA precursor. Despite the… Expand
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Highly Cited
2003
Highly Cited
2003
Novel "anti-reverse" cap analogs with superior translational properties.
Synthetic analogs of the 5'-terminal caps of eukaryotic mRNAs and snRNAs are used in elucidating such physiological processes as… Expand
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Highly Cited
2002
Highly Cited
2002
Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides
ABSTRACT We report here the results of a systematic high-resolution X-ray crystallographic analysis of complexes of the hepatitis… Expand
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Highly Cited
1991
Highly Cited
1991
2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase.
It has been found that 2'-deoxy-2'-methyleneuridine (MdUrd), 2'-deoxy-2'-methylenecytidine (MdCyd), and 2'-deoxy-2',2… Expand
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Highly Cited
1990
Highly Cited
1990
Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine.
The new deoxycytidine analogue 2',2'-difluorodeoxycytidine (dFdC) is a specific inhibitor of DNA synthesis that has marked… Expand
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Highly Cited
1990
Highly Cited
1990
Evidence for covalent attachment of the adeno-associated virus (AAV) rep protein to the ends of the AAV genome.
We have demonstrated that when the covalently joined ends of linear adeno-associated virus (AAV) DNA are resolved in vitro, the… Expand
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Highly Cited
1979
Highly Cited
1979
Glutathione-dependent hydrogen donor system for calf thymus ribonucleoside-diphosphate reductase.
Purified calf thymus ribonucleoside-diphosphate reductase (2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2… Expand
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Highly Cited
1969
Highly Cited
1969
Role of effector binding in allosteric control of ribonucleoside diphosphate reductase.
Abstract The allosteric effectors, ATP, dATP, dGTP and dTTP, regulate both the level of activity and the substrate specificity of… Expand
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Highly Cited
1968
Highly Cited
1968
Inhibition of ribonucleoside diphosphate reductase by hydroxyurea.
Hydroxyurea, a compound which inhibits the growth of rapidly proliferating tissues in animals and man, is known to inhibit DNA… Expand
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