ribonucleotide reductase M2

Known as: R2, Ribonucleotide Reductase, Small Subunit, RRM2 
Ribonucleoside-diphosphate reductase subunit M2 (389 aa, ~45 kDa) is encoded by the human RRM2 gene. This protein plays a role in the reduction of… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
F-box proteins are the substrate binding subunits of SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complexes. Using affinity… (More)
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2010
2010
AIMS To examine the immunohistochemical expression and function of ribonucleotide reductase M2 subunit (RRM2), a gemcitabine… (More)
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2010
2010
Ribonucleotide reductase M2 subunit is one of two subunits that constitute ribonucleotide reductase, the enzyme that catalyzes… (More)
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Highly Cited
2009
Highly Cited
2009
In rice (Oryza sativa), the shoot-borne crown roots are the major root type and are initiated at lower stem nodes as part of… (More)
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Highly Cited
2008
Highly Cited
2008
Ribonucleotide reductase subunits M1 (RRM1) and M2 (RRM2) are involved in the metabolism of gemcitabine (2′,2… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE Ribonucleotide reductase (RR) is a therapeutic target for DNA replication-dependent diseases such as cancer. Here, a… (More)
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2007
2007
BACKGROUND Ribonucleoside diphosphate reductase plays a key role in converting ribonucleoside diphosphate to 2… (More)
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2007
2007
Gemcitabine is an efficacious cytotoxic agent used in the treatment of unresectable pancreatic carcinoma (PC). Recently… (More)
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2005
2005
Ribonucleotide reductase catalyzes a rate-limiting reaction in DNA synthesis by converting ribonucleotides to… (More)
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Highly Cited
2004
Highly Cited
2004
Ribonucleotide reductase is emerging as an important determinant of gemcitabine chemoresistance in human cancers. Activity of… (More)
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