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Ribonucleoprotein, U5 Small Nuclear

Known as: U5 Small Nuclear Ribonucleoproteins, Small Nuclear Ribonucleoproteins, U5, Ribonucleoprotein, U5 Small Nuclear [Chemical/Ingredient] 
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U5 snRNP along with U4-U6 snRNP preassemble into a single… Expand
National Institutes of Health

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In BloodProcess of secretionU5 snRNP locationagonists
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PRP6 protein, S cerevisiae

Papers overview

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2017
2017
Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones
Splicing is catalyzed by the spliceosome, a complex of five major small nuclear ribonucleoprotein particles (snRNPs). The pre… Expand
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Highly Cited
2013
Highly Cited
2013
Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site
Summary The U5 small nuclear ribonucleoprotein particle (snRNP) helicase Brr2 disrupts the U4/U6 small nuclear RNA (snRNA) duplex… Expand
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Highly Cited
2007
Highly Cited
2007
prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast
Prp8 protein (Prp8p) is a highly conserved pre-mRNA splicing factor and a component of spliceosomal U5 small nuclear… Expand
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Highly Cited
2002
Highly Cited
2002
Small Nuclear Ribonucleoprotein Remodeling During Catalytic Activation of the Spliceosome
Major structural changes occur in the spliceosome during its activation just before catalyzing the splicing of pre–messenger RNAs… Expand
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Highly Cited
2002
Highly Cited
2002
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
We describe characterization of spliceosomes affinity purified under native conditions. These spliceosomes consist largely of C… Expand
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Highly Cited
2001
Highly Cited
2001
Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae.
We have purified the yeast U5 and U6 pre-mRNA splicing small nuclear ribonucleoproteins (snRNPs) by affinity chromatography and… Expand
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2000
2000
A General Approach for Identification of RNA-Protein Cross-linking Sites within Native Human Spliceosomal Small Nuclear Ribonucleoproteins (snRNPs)
We describe a novel approach to identify RNA-protein cross-linking sites within native small nuclear ribonucleoprotein (snRNP… Expand
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Highly Cited
1998
Highly Cited
1998
The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40…
The human small nuclear ribonucleoprotein (snRNP) U5 is biochemically the most complex of the snRNP particles, containing not… Expand
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Highly Cited
1995
Highly Cited
1995
A novel role for a U5 snRNP protein in 3' splice site selection.
The choice of a 3' splice site in Saccharomyces cerevisiae introns involves recognition of a uridine-rich tract upstream of the… Expand
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Highly Cited
1992
Highly Cited
1992
Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing.
We have used a site-specific cross-linking strategy to identify RNA and protein factors that interact with the 5' splice site… Expand
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