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- Publications
- Influence
Structural determinants of water permeation through aquaporin-1
- K. Murata, K. Mitsuoka, +5 authors Y. Fujiyoshi
- Chemistry, Medicine
- Nature
- 5 October 2000
Human red cell AQP1 is the first functionally defined member of the aquaporin family of membrane water channels. Here we describe an atomic model of AQP1 at 3.8 Å resolution from electron… Expand
STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1
- C. Park, P. Hoover, +7 authors R. S. Lewis
- Biology, Medicine
- Cell
- 6 March 2009
Store-operated Ca(2+) channels activated by the depletion of Ca(2+) from the endoplasmic reticulum (ER) are a major Ca(2+) entry pathway in nonexcitable cells and are essential for T cell activation… Expand
Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling
- J. Takagi, B. M. Petre, T. Walz, T. Springer
- Biology, Medicine
- Cell
- 6 September 2002
How ligand binding alters integrin conformation in outside-in signaling, and how inside-out signals alter integrin affinity for ligand, have been mysterious. We address this with electron microscopy,… Expand
A Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus
- J. Mougous, M. Cuff, +10 authors J. Mekalanos
- Medicine, Biology
- Science
- 9 June 2006
Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion… Expand
Latent TGF-β structure and activation
- Minlong Shi, J. Zhu, +4 authors T. Springer
- Biology, Medicine
- Nature
- 16 June 2011
Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-β1 requires the binding of αv integrin to an RGD sequence in the… Expand
Multiple associated proteins regulate proteasome structure and function.
- D. S. Leggett, John Hanna, +6 authors D. Finley
- Biology, Medicine
- Molecular cell
- 1 September 2002
We have identified proteins that are abundant in affinity-purified proteasomes, but absent from proteasomes as previously defined because elevated salt concentrations dissociate them during… Expand
Molecular model for a complete clathrin lattice from electron cryomicroscopy
Clathrin-coated vesicles are important vehicles of membrane traffic in cells. We report the structure of a clathrin lattice at subnanometre resolution, obtained from electron cryomicroscopy of coats… Expand
Neurodegenerative disease: Amyloid pores from pathogenic mutations
- H. Lashuel, D. Hartley, B. M. Petre, T. Walz, P. T. Lansbury
- Biology, Medicine
- Nature
- 18 July 2002
Alzheimer's and Parkinson's diseases are associated with the formation in the brain of amyloid fibrils from β-amyloid and α-synuclein proteins, respectively. It is likely that oligomeric… Expand
The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis
- J. Li, Thomas McQuade, +9 authors H. Wu
- Biology, Medicine
- Cell
- 20 July 2012
RIP1 and RIP3 kinases are central players in TNF-induced programmed necrosis. Here, we report that the RIP homotypic interaction motifs (RHIMs) of RIP1 and RIP3 mediate the assembly of heterodimeric… Expand
Negative Staining and Image Classification – Powerful Tools in Modern Electron Microscopy
- M. Ohi, Y. Li, Yifan Cheng, T. Walz
- Biology, Medicine
- Biological Procedures Online
- 19 March 2004
Vitrification is the state-of-the-art specimen preparation technique for molecular electron microscopy (EM) and therefore negative staining may appear to be an outdated approach. In this paper we… Expand