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Peroxisome proliferator-activated and retinoid X receptors (PPARs and RXRs) are transcription factors belonging to the steroid… Expand Tangier disease, a condition characterized by low levels of high density lipoprotein and cholesterol accumulation in macrophages… Expand The retinoid X receptor (RXR) is a nuclear receptor that functions as a ligand-activated transcription factor. Little is known… Expand Induction of terminal differentiation represents a promising therapeutic approach to certain human malignancies. The peroxisome… Expand Retinoids play an important role in development, differentiation, and homeostasis. The discovery of retinoid receptors belonging… Expand The nuclear receptor superfamily is comprised of over 150 different proteins that have evolved to mediate a complex array of… Expand The nuclear hormone receptors called PPARs (peroxisome proliferator-activated receptors alpha, beta, and gamma) regulate the… Expand The binding of endogenous retinoids and stereoisomers of retinoic acid (RA) to the retinoid nuclear receptors, RA receptor (RARs… Expand All-trans retinoic acid (RA) has previously been shown to modulate the transcriptional properties of the retinoic acid receptor… Expand CELLULAR responsiveness to retinoic acid and its metabolites is conferred through two structurally and pharmacologically… Expand