A ligand of peroxisome proliferator-activated receptor gamma, retinoids, and prevention of preneoplastic mammary lesions.

@article{Mehta2000ALO,
  title={A ligand of peroxisome proliferator-activated receptor gamma, retinoids, and prevention of preneoplastic mammary lesions.},
  author={Rajendra G. Mehta and Elizabeth A. Williamson and M K Patel and H. Phillip Koeffler},
  journal={Journal of the National Cancer Institute},
  year={2000},
  volume={92 5},
  pages={
          418-23
        }
}
BACKGROUND Chemoprevention of breast cancer is an active area of investigation. Recent in vivo and in vitro studies have shown that thiazolidinediones (e.g., troglitazone) and retinoids are able to inhibit the growth of breast cancer cells. Troglitazone mediates its action via peroxisome proliferator-activated receptor gamma (PPARgamma). We evaluated the ability of troglitazone, alone or in combination with retinoids, to prevent the induction of preneoplastic lesions by 7,12-dimethylbenz[a… Expand
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TLDR
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