Retinoic Acid Response Element

Known as: RARE 
A cis-acting transcription regulatory element. It is bound by the retinoic acid receptors.
National Institutes of Health

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Chromosomespromoter

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Highly Cited
2000
Highly Cited
2000
Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1.
The 9-cis retinoic acid receptor (retinoid X receptor, RXR) forms heterodimers with the all-trans retinoic acid receptor (RAR… (More)
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Highly Cited
2000
Highly Cited
2000
Cytochrome P450RAI(CYP26) promoter: a distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolism.
The catabolism of retinoic acid (RA) is an essential mechanism for restricting the exposure of specific tissues and cells to RA… (More)
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1998
1998
Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element.
Analysis of the regulatory regions of the Hox genes has revealed a complex array of positive and negative cis-acting elements… (More)
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Highly Cited
1997
Highly Cited
1997
Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid.
Retinoic acid is one of the most promising drugs for chemotherapy and chemoprevention of cancer. Either blocking activator… (More)
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Highly Cited
1996
Highly Cited
1996
The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.
We have studied an acute promyelocytic leukemia (APL) patient with a variant t(5;17)(q32;q12). This translocation fuses the gene… (More)
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Highly Cited
1994
Highly Cited
1994
A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1
WITHIN the Hoxb homeobox gene complex, Hoxb-1 is the earliest member expressed in the mesoderm and neuroectoderm of primitive… (More)
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Highly Cited
1994
Highly Cited
1994
Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1.
After activation in mesoderm and neuroectoderm, expression of the Hoxb-1 gene is progressively restricted to rhombomere (r) 4 in… (More)
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Highly Cited
1991
Highly Cited
1991
RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements
The retinoic acid receptor (RAR) requires coregulators to bind effectively to response elements in target genes. A strategy of… (More)
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Highly Cited
1991
Highly Cited
1991
Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element.
We have characterized the promoter of the mouse retinoic acid receptor alpha 2 (mRAR-alpha 2) isoform. This promoter contains a… (More)
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1991
1991
Retinoic acid response element in the human alcohol dehydrogenase gene ADH3: implications for regulation of retinoic acid synthesis.
Retinoic acid regulation of one member of the human class I alcohol dehydrogenase (ADH) gene family was demonstrated, suggesting… (More)
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