• Publications
  • Influence
Math1 Is Essential for the Development of Hindbrain Neurons Critical for Perinatal Breathing
Mice lacking the proneural transcription factor Math1 (Atoh1) lack multiple neurons of the proprioceptive and arousal systems and die shortly after birth from an apparent inability to initiateExpand
  • 134
  • 23
Neural mechanisms generating respiratory pattern in mammalian brain stem-spinal cord in vitro. I. Spatiotemporal patterns of motor and medullary neuron activity.
1. An analysis of the spatial and temporal patterns of activity of neurons of the respiratory motor-pattern generation system in an in vitro neonatal rat brain stem-spinal cord preparation isExpand
  • 297
  • 20
Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities
Rett syndrome (RTT) is characterized by specific motor, cognitive, and behavioral deficits. Because several of these abnormalities occur in other disease states associated with alterations inExpand
  • 206
  • 15
  • PDF
A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3
Congenital diaphragmatic hernia (CDH) is a significant cause of pediatric mortality in humans with a heterogeneous and poorly understood etiology. Here we show that mice lacking Slit3 developed aExpand
  • 129
  • 15
  • PDF
Embryological origins and development of the rat diaphragm
Textbooks of embryology provide a standard set of drawings and text reflecting the traditional interpretation of phrenic nerve and diaphragm development based on anatomical dissections of embryonicExpand
  • 125
  • 15
Ontogeny of rhythmic motor patterns generated in the embryonic rat spinal cord.
  • J. Ren, J. Greer
  • Medicine, Psychology
  • Journal of neurophysiology
  • 1 March 2003
Patterned spontaneous activity is generated in developing neuronal circuits throughout the CNS including the spinal cord. This activity is thought to be important for activity-dependent neuronalExpand
  • 125
  • 15
  • PDF
Modulation of Respiratory Rhythmogenesis by Chloride-Mediated Conductances during the Perinatal Period
  • J. Ren, J. Greer
  • Medicine, Biology
  • The Journal of Neuroscience
  • 5 April 2006
Respiratory rhythmogenesis is modulated by chloride-mediated conductances via GABAA and glycine receptors. In this study, we determine the actions of chloride-mediated conductances on respiratoryExpand
  • 98
  • 13
  • PDF
PreBötzinger Complex Neurokinin-1 Receptor-Expressing Neurons Mediate Opioid-Induced Respiratory Depression
The analgesic properties of the opium poppy Papever somniferum were first mentioned by Hippocrates around 400 BC, and opioid analgesics remain the mainstay of pain management today. These drugs canExpand
  • 106
  • 13
Central Respiratory Rhythmogenesis Is Abnormal in Lbx1- Deficient Mice
Lbx1 is a transcription factor that determines neuronal cell fate and identity in the developing medulla and spinal cord. Newborn Lbx1 mutant mice die of respiratory distress during the earlyExpand
  • 56
  • 12
  • PDF
Respiratory and locomotor patterns generated in the fetal rat brain stem-spinal cord in vitro.
An in vitro brain stem-spinal cord preparation from last trimester (E13-E21) fetal rats, which generates rhythmic respiratory and locomotor patterns, is described. These coordinated motor patternsExpand
  • 136
  • 11