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Recombinant Stem Cell Factor

Known as: c-Kit Ligand, Steel Factor, Recombinant Human Stem Cell Factor 
A therapeutic glycoprotein cytokine chemically identical to or similar to endogenous human stem cell factor with hematopoietic activity. Recombinant… Expand
National Institutes of Health

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Related topics

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Cytokine Receptor ActivationHematopoiesis InductionHematopoietic stem cellsIL3 gene
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Papers overview

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Highly Cited
1999
Highly Cited
1999
T Helper Cell Type 2 Cytokine–Mediated Comitogenic Responses and Ccr3 Expression during Differentiation of Human Mast Cells in Vitro
Mast cells (MCs) arise in situ from circulating stem cell factor (SCF)-dependent committed progenitors (PrMCs) and accumulate at… Expand
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Highly Cited
1997
Highly Cited
1997
Effect of recombinant human IL-4 on tryptase, chymase, and Fc epsilon receptor type I expression in recombinant human stem cell factor-dependent fetal liver-derived human mast cells.
The effect of recombinant human IL-4 (rhIL-4) on the development of recombinant human stem cell factor-dependent fetal liver… Expand
Highly Cited
1995
Highly Cited
1995
Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development.
The development of megakaryocytes (MKs) from their marrow precursors is one of the least understood aspects of hematopoiesis… Expand
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Highly Cited
1994
Highly Cited
1994
Steel factor and c-kit regulate cell-matrix adhesion.
Steel (SI) and white spotting (W) loci encode steel factor (c-kit ligand) and the c-kit tyrosine kinase receptor, respectively… Expand
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Highly Cited
1993
Highly Cited
1993
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.
The c-kit proto-oncogene encodes a receptor tyrosine kinase. Binding of c-kit ligand, stem cell factor (SCF) to c-kit receptor (c… Expand
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Highly Cited
1993
Highly Cited
1993
Development of human mast cells from umbilical cord blood cells by recombinant human and murine c-kit ligand.
Both human and mouse c-kit ligand induced differentiation of human mast cells in a long-term culture of the mononuclear cells of… Expand
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Highly Cited
1992
Highly Cited
1992
Recombinant human stem cell factor stimulates differentiation of mast cells from dispersed human fetal liver cells.
We have previously shown the development in vitro of tryptase+ human mast cells from fetal liver cells cocultured with murine 3T3… Expand
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Highly Cited
1992
Highly Cited
1992
Role of c-kit ligand in the expansion of human hematopoietic progenitor cells.
To test the hypothesis that the c-kit ligand plays an important role in the regulation of early events occurring during human… Expand
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Highly Cited
1991
Highly Cited
1991
Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture
DESPITE the importance of germ cells to the survival of species, surprisingly little is known about their embryological origin… Expand
Highly Cited
1991
Highly Cited
1991
The role of recombinant stem cell factor in early B cell development. Synergistic interaction with IL-7.
The cDNA for stem cell factor was recently isolated from Buffalo rat liver cells (BRL-3A) and recombinant rat stem cell factor… Expand
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