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Recombinant Stem Cell Factor

Known as: c-Kit Ligand, Steel Factor, Recombinant Human Stem Cell Factor 
A therapeutic glycoprotein cytokine chemically identical to or similar to endogenous human stem cell factor with hematopoietic activity. Recombinant… 
National Institutes of Health

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Related topics

14 relations
Cytokine Receptor ActivationHematopoiesis InductionHematopoietic stem cellsIL3 gene

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Papers overview

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Highly Cited
2001
Highly Cited
2001
Inhibition of IgE‐induced activation of human mast cells by IL‐10
Background IL‐10 exhibits anti‐inflammatory effects on activated rodent mast cells (MC) in vitro and inhibits allergen‐induced… 
Highly Cited
1997
Highly Cited
1997
Effect of recombinant human IL-4 on tryptase, chymase, and Fc epsilon receptor type I expression in recombinant human stem cell factor-dependent fetal liver-derived human mast cells.
The effect of recombinant human IL-4 (rhIL-4) on the development of recombinant human stem cell factor-dependent fetal liver… 
Highly Cited
1994
Highly Cited
1994
Steel factor and c-kit regulate cell-matrix adhesion.
Steel (SI) and white spotting (W) loci encode steel factor (c-kit ligand) and the c-kit tyrosine kinase receptor, respectively… 
Highly Cited
1993
Highly Cited
1993
Development of human mast cells from umbilical cord blood cells by recombinant human and murine c-kit ligand.
Both human and mouse c-kit ligand induced differentiation of human mast cells in a long-term culture of the mononuclear cells of… 
Highly Cited
1992
Highly Cited
1992
Recombinant human stem cell factor stimulates differentiation of mast cells from dispersed human fetal liver cells.
We have previously shown the development in vitro of tryptase+ human mast cells from fetal liver cells cocultured with murine 3T3… 
Highly Cited
1992
Highly Cited
1992
Role of c-kit ligand in the expansion of human hematopoietic progenitor cells.
To test the hypothesis that the c-kit ligand plays an important role in the regulation of early events occurring during human… 
Highly Cited
1991
Highly Cited
1991
Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture
DESPITE the importance of germ cells to the survival of species, surprisingly little is known about their embryological origin… 
Highly Cited
1991
Highly Cited
1991
Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with interleukin-3…
We tested the ability of recombinant human stem cell factor (SCF) to stimulate isolated marrow precursor cells to form colonies… 
Highly Cited
1991
Highly Cited
1991
The role of recombinant stem cell factor in early B cell development. Synergistic interaction with IL-7.
The cDNA for stem cell factor was recently isolated from Buffalo rat liver cells (BRL-3A) and recombinant rat stem cell factor… 
Highly Cited
1991
Highly Cited
1991
The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo. Analysis by anatomical distribution, histochemistry, and protease phenotype
Mast cell development is a complex process that results in the appearance of phenotypically distinct populations of mast cells in… 
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