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Recombinant Stem Cell Factor

Known as: c-Kit Ligand, Steel Factor, Recombinant Human Stem Cell Factor 
A therapeutic glycoprotein cytokine chemically identical to or similar to endogenous human stem cell factor with hematopoietic activity. Recombinant… 
National Institutes of Health

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Cytokine Receptor ActivationHematopoiesis InductionHematopoietic stem cellsIL3 gene

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Papers overview

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2006
2006
Expression, Renaturation and Simultaneous Purification of Recombinant Human Stem Cell Factor in Escherichia coli
Recombinant human stem cell factor (rhSCF) was produced as an inclusion body by Escherichia coli DH5α grown in a 5 l fermentor… 
2005
2005
Successful mobilization of peripheral blood stem cells using recombinant human stem cell factor in heavily pretreated patients who have failed a previous attempt with a granulocyte colony-stimulating…
Summary:To assess the efficacy of recombinant human stem cell factor (rHuSCF), 48 patients who had failed to mobilize >2.0 × 106… 
Highly Cited
1999
Highly Cited
1999
Recombinant human (rh)IL-4-mediated apoptosis and recombinant human IL-6-mediated protection of recombinant human stem cell factor-dependent human mast cells derived from cord blood mononuclear cell…
Although stem cell factor (SCF) appears to be the major growth factor for human mast cells, other factors undoubtedly play… 
Highly Cited
1998
Highly Cited
1998
A combination of stem cell factor and granulocyte colony‐stimulating factor enhances the growth of human progenitor B cells supported by murine stromal cell line MS‐5
We have developed a long‐term culture system using the murine bone marrow stromal cells MS‐5 to support the growth of progenitor… 
Highly Cited
1998
Highly Cited
1998
Selective deamidation of recombinant human stem cell factor during in vitro aging: isolation and characterization of the aspartyl and isoaspartyl homodimers and heterodimers.
During in vitro aging, deamidation of recombinant human stem cell factor produced in Escherichia. coli was detected by HPLC… 
1998
1998
Regulation of cyclooxygenase-2 and endogenous cytokine expression by bacterial lipopolysaccharide that acts in synergy with c-kit ligand and Fc epsilon receptor I crosslinking in cultured mast cells.
Emerging evidence has suggested the pivotal role of mast cells in a host defense against bacterial infection. In this paper, we… 
Highly Cited
1994
Highly Cited
1994
Coordinate regulation of Steel factor, its receptor (Kit), and cytoadhesion molecule (ICAM-1 and ELAM-1) mRNA expression in human vascular endothelial cells of differing origins.
Endothelial cells (EC) are a major component of the bone marrow and peripheral vasculature microenvironments and contribute to… 
1994
1994
Reconstitution by bone marrow grafting of the defective protective capacity at the migratory phase but not at the intestinal phase of Nippostrongylus brasiliensis infection in W/Wv mice
After a primary infection by subcutaneous inoculation with the infective larvae (L3) of Nippostrongylus brasiliensis, the… 
Highly Cited
1993
Highly Cited
1993
Effects of recombinant canine stem cell factor, a c-kit ligand, and recombinant granulocyte colony-stimulating factor on hematopoietic recovery after otherwise lethal total body irradiation.
The effects of recombinant canine stem cell factor (rcSCF) on hematopoiesis were studied in normal dogs and in dogs given… 
1992
1992
Stem cell factor stimulates the in vitro growth of bone marrow cells from aplastic anemia patients.
Aplastic anemia (AA) is a rare human bone marrow disorder of unknown etiology manifested by a strongly impaired growth of… 
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