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Recombinant Stem Cell Factor

Known as: c-Kit Ligand, Steel Factor, Recombinant Human Stem Cell Factor 
A therapeutic glycoprotein cytokine chemically identical to or similar to endogenous human stem cell factor with hematopoietic activity. Recombinant… Expand
National Institutes of Health

Related topics

Related topics

14 relations
Cytokine Receptor ActivationHematopoiesis InductionHematopoietic stem cellsIL3 gene
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Papers overview

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Review
2011
Review
2011
Targeting immune suppressing myeloid-derived suppressor cells in oncology.
Emerging data suggests that host immune cells with a suppressive phenotype represent a significant hurdle to successful therapy… Expand
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Highly Cited
1999
Highly Cited
1999
T Helper Cell Type 2 Cytokine–Mediated Comitogenic Responses and Ccr3 Expression during Differentiation of Human Mast Cells in Vitro
Mast cells (MCs) arise in situ from circulating stem cell factor (SCF)-dependent committed progenitors (PrMCs) and accumulate at… Expand
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1997
1997
Effect of recombinant human IL-4 on tryptase, chymase, and Fc epsilon receptor type I expression in recombinant human stem cell factor-dependent fetal liver-derived human mast cells.
The effect of recombinant human IL-4 (rhIL-4) on the development of recombinant human stem cell factor-dependent fetal liver… Expand
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Highly Cited
1994
Highly Cited
1994
Steel factor and c-kit regulate cell-matrix adhesion.
Steel (SI) and white spotting (W) loci encode steel factor (c-kit ligand) and the c-kit tyrosine kinase receptor, respectively… Expand
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Highly Cited
1993
Highly Cited
1993
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.
The c-kit proto-oncogene encodes a receptor tyrosine kinase. Binding of c-kit ligand, stem cell factor (SCF) to c-kit receptor (c… Expand
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Highly Cited
1992
Highly Cited
1992
Recombinant human stem cell factor stimulates differentiation of mast cells from dispersed human fetal liver cells.
We have previously shown the development in vitro of tryptase+ human mast cells from fetal liver cells cocultured with murine 3T3… Expand
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Highly Cited
1991
Highly Cited
1991
Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture
DESPITE the importance of germ cells to the survival of species, surprisingly little is known about their embryological origin… Expand
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Highly Cited
1991
Highly Cited
1991
Recombinant human stem cell factor, a c-kit ligand, stimulates hematopoiesis in primates.
Recombinant human stem cell factor (SCF) is homologous with recombinant rat SCF (rrSCF) and is a ligand for c-kit. We determined… Expand
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Highly Cited
1991
Highly Cited
1991
The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo. Analysis by anatomical distribution, histochemistry, and protease phenotype
Mast cell development is a complex process that results in the appearance of phenotypically distinct populations of mast cells in… Expand
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Highly Cited
1991
Highly Cited
1991
The effects on hematopoiesis of recombinant stem cell factor (ligand for c-kit) administered in vivo to mice either alone or in combination with granulocyte colony-stimulating factor.
Stem cell factor (SCF) is the ligand for the receptor encoded by the c-kit proto-oncogene. Mutations of either c-kit or the SCF… Expand
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