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Recombinant Stem Cell Factor
Known as:
c-Kit Ligand
, Steel Factor
, Recombinant Human Stem Cell Factor
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A therapeutic glycoprotein cytokine chemically identical to or similar to endogenous human stem cell factor with hematopoietic activity. Recombinant…
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National Institutes of Health
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Related topics
Related topics
14 relations
Cytokine Receptor Activation
Hematopoiesis Induction
Hematopoietic stem cells
IL3 gene
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Narrower (1)
ancestim
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Expression, Renaturation and Simultaneous Purification of Recombinant Human Stem Cell Factor in Escherichia coli
W. Lili
,
Chaozhan Wang
,
Geng Xindu
Biotechnology Letters
2006
Corpus ID: 26941387
Recombinant human stem cell factor (rhSCF) was produced as an inclusion body by Escherichia coli DH5α grown in a 5 l fermentor…
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Highly Cited
2003
Highly Cited
2003
Successful mobilization of peripheral blood stem cells after addition of ancestim (stem cell factor) in patients who had failed a prior mobilization with filgrastim (granulocyte colony-stimulating…
L. B. To
,
John Bashford
,
+11 authors
Brian Cohen
Bone Marrow Transplantation
2003
Corpus ID: 36360006
Summary:This study assessed the ability of recombinant human stem cell factor (rHuSCF) to mobilize stem cells in 44 patients who…
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Highly Cited
2001
Highly Cited
2001
Inhibition of IgE‐induced activation of human mast cells by IL‐10
Bernard Royer
,
Sonia Varadaradjalou
,
Philippe Saas
,
J. Guillosson
,
Jean-pierre Kantelip
,
Michel Arock
Clinical and Experimental Allergy
2001
Corpus ID: 24844320
Background IL‐10 exhibits anti‐inflammatory effects on activated rodent mast cells (MC) in vitro and inhibits allergen‐induced…
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Highly Cited
1999
Highly Cited
1999
Recombinant human (rh)IL-4-mediated apoptosis and recombinant human IL-6-mediated protection of recombinant human stem cell factor-dependent human mast cells derived from cord blood mononuclear cell…
C. Oskeritzian
,
Z. Wang
,
+5 authors
L. Schwartz
Journal of Immunology
1999
Corpus ID: 25505724
Although stem cell factor (SCF) appears to be the major growth factor for human mast cells, other factors undoubtedly play…
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Highly Cited
1998
Highly Cited
1998
A combination of stem cell factor and granulocyte colony‐stimulating factor enhances the growth of human progenitor B cells supported by murine stromal cell line MS‐5
Masamichi Nishihara
,
Y. Wada
,
+7 authors
T. Maekawa
European Journal of Immunology
1998
Corpus ID: 33067413
We have developed a long‐term culture system using the murine bone marrow stromal cells MS‐5 to support the growth of progenitor…
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Highly Cited
1998
Highly Cited
1998
Selective deamidation of recombinant human stem cell factor during in vitro aging: isolation and characterization of the aspartyl and isoaspartyl homodimers and heterodimers.
Y. Hsu
,
W. Chang
,
+5 authors
H. Lu
Biochemistry
1998
Corpus ID: 44334619
During in vitro aging, deamidation of recombinant human stem cell factor produced in Escherichia. coli was detected by HPLC…
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1995
1995
Generation of hematopoietic colony-forming cells from embryonic stem cells: synergy between a soluble factor from NIH-3T3 cells and hematopoietic growth factors.
Anna Bigas
,
David I. K. Martin
,
Irwin D. Bernstein
Blood
1995
Corpus ID: 30355769
Murine embryonic stem cells are able to differentiate into embryoid bodies (EBs) in vitro in the absence of leukemia-inhibitory…
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Highly Cited
1994
Highly Cited
1994
Coordinate regulation of Steel factor, its receptor (Kit), and cytoadhesion molecule (ICAM-1 and ELAM-1) mRNA expression in human vascular endothelial cells of differing origins.
J. Buzby
,
E. Knoppel
,
M. Cairo
Experimental Hematology
1994
Corpus ID: 23047589
Endothelial cells (EC) are a major component of the bone marrow and peripheral vasculature microenvironments and contribute to…
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Highly Cited
1993
Highly Cited
1993
Effects of recombinant canine stem cell factor, a c-kit ligand, and recombinant granulocyte colony-stimulating factor on hematopoietic recovery after otherwise lethal total body irradiation.
F. Schuening
,
F. Appelbaum
,
+5 authors
R. Storb
Blood
1993
Corpus ID: 9251189
The effects of recombinant canine stem cell factor (rcSCF) on hematopoiesis were studied in normal dogs and in dogs given…
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Highly Cited
1992
Highly Cited
1992
A c-kit ligand, recombinant human stem cell factor, mediates reversible expansion of multiple CD34+ colony-forming cell types in blood and marrow of baboons.
R. Andrews
,
S. Bartelmez
,
+4 authors
K. Zsebo
Blood
1992
Corpus ID: 6554675
The ligand for the human c-kit, recombinant human stem cell factor (SCF), was administered to baboons at doses of 200, 100, 50…
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