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Tumour lysis syndrome: new therapeutic strategies and classification
TLDR
Recent advances in the management of TLS are summarised and a new classification system is provided and recommendations for prophylaxis and/or treatment based on this classification scheme are provided. Expand
Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review.
TLDR
Standardized guidelines are needed to aid in the stratification of patients according to risk and to establish prophylaxis and treatment recommendations for patients at risk or with established TLS. Expand
Recommendations for the evaluation of risk and prophylaxis of tumour lysis syndrome (TLS) in adults and children with malignant diseases: an expert TLS panel consensus
TLDR
An international TLS consensus expert panel of paediatric and adult oncologists, experts in TLS pathophysiology and experts in encryption, developed a final model of low, intermediate and high risk TLS classification and associated TLS prophylaxis recommendations. Expand
A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes: delayed transplantation for low-risk myelodysplasia is associated with improved outcome.
TLDR
A Markov model constructed to examine 3 transplantation strategies for newly diagnosed MDS found that delayed BMT is associated with maximal life expectancy, whereas immediate transplantation for intermediate-2- and high-risk disease is associated for low- and intermediate-1-risk patients. Expand
Risk factors for acute GVHD and survival after hematopoietic cell transplantation.
TLDR
Conditioning intensity, TBI and graft source have a combined effect on risk of AGVHD that must be considered in deciding on a treatment strategy for individual patients. Expand
A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis.
TLDR
This randomized study demonstrated more rapid control and lower levels of plasma uric acid in patients at high risk for tumor lysis who received rasburicase compared to allopurinol. Expand
Hematopoietic stem-cell transplantation for acute leukemia in relapse or primary induction failure.
TLDR
Hematopoietic stem-cell transplantation during relapse can achieve long-term survival in selected patients with acute leukemia and delineate subgroups with different outcomes. Expand
Generation of keratinocytes from normal and recessive dystrophic epidermolysis bullosa-induced pluripotent stem cells
TLDR
The studies indicate that autologous iPSCs have the potential to provide a source of cells for regenerative therapies for specific skin diseases and are differentiated into keratinocytes with high efficiency, suggesting that they were fully functional. Expand
Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors.
TLDR
Umbilical-cord blood from unrelated donors can restore hematopoiesis in adults who receive myeloablative therapy and is associated with acceptable rates of severe acute and chronic GVHD. Expand
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