Recombinant Human Endostatin

Known as: Endostatin, Recombinant Endostatin, rhEndostatin 
A recombinant human proteolytic fragment of the C-terminal end of type XVIII collagen. Endostatin induces microvascular endothelial cell apoptosis… (More)
National Institutes of Health

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2012
2012
BACKGROUND Hypoxic tumor cells can reduce the efficacy of radiation. Antiangiogenic therapy may transiently "normalize" the tumor… (More)
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2010
2010
Normalization of the tumor vasculature and microenvironment by several angiogenesis inhibitors has been reported. Given that… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE Endostatin is a 20-kd proteolytic fragment of collagen XVIII that, in preclinical studies, has been shown to have… (More)
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2006
2006
The pharmacokinetics of recombinant human endostatin (rh-Endo) has not been established in the rat, although this species of… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE To perform a phase I trial of recombinant human endostatin (rhEndostatin; EntreMed, Rockville, MD) given as a daily 20… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE Endostatin, a 20-kd fragment of collagen XVIII, is a potent inhibitor of angiogenesis. We evaluated recombinant human… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE Angiogenesis is a target for the treatment of cancer and other diseases, and its complex biology suggests that… (More)
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2001
2001
Endostatin is a potent and specific antiangiogenic protein capable of inhibiting the growth of murine and xenotransplanted human… (More)
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1999
1999
Endostatin, a potent endogenous inhibitor of angiogenesis, inhibits the growth of primary tumors without induction of acquired… (More)
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1999
1999
Endostatin, a C-terminal product of collagen XVIII, is a very powerful angiogenesis inhibitor. In vivo experiments in mice… (More)
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