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Recombinant Human Endostatin

Known as: Endostatin, Recombinant Endostatin, rhEndostatin 
A recombinant human proteolytic fragment of the C-terminal end of type XVIII collagen. Endostatin induces microvascular endothelial cell apoptosis… Expand
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Background Hypoxic tumor cells can reduce the efficacy of radiation. Antiangiogenic therapy may transiently “normalize” the tumor… Expand
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Highly Cited
2006
Highly Cited
2006
PURPOSE Endostatin is a 20-kd proteolytic fragment of collagen XVIII that, in preclinical studies, has been shown to have… Expand
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Highly Cited
2004
Highly Cited
2004
Purpose: Recombinant human endostatin (rhES) is an antiangiogenic agent derived from collagen XVIII which inhibits tumor growth… Expand
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Highly Cited
2003
Highly Cited
2003
Inhibition of angiogenesis has emerged as a key focus for the treatment of cancer, necessitating a better understanding of the… Expand
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Highly Cited
2003
Highly Cited
2003
Endostatin is a fragment of collagen XVIII that acts as an endogenous inhibitor of tumor angiogenesis and tumor growth. Anti… Expand
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Highly Cited
2002
Highly Cited
2002
PURPOSE Endostatin, a 20-kd fragment of collagen XVIII, is a potent inhibitor of angiogenesis. We evaluated recombinant human… Expand
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Highly Cited
2002
Highly Cited
2002
  • J. Eder, J. Supko, +17 authors D. Kufe
  • Journal of clinical oncology : official journal…
  • 2002
  • Corpus ID: 12210605
PURPOSE To perform a phase I trial of recombinant human endostatin (rhEndostatin; EntreMed, Rockville, MD) given as a daily 20… Expand
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Highly Cited
2002
Highly Cited
2002
PURPOSE Angiogenesis is a target for the treatment of cancer and other diseases, and its complex biology suggests that… Expand
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Highly Cited
2002
Highly Cited
2002
Endostatin is an anti‐angiogenic factor that inhibits endothelial cell (EC) migration and induces EC apoptosis. Because nitric… Expand
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Highly Cited
2002
Highly Cited
2002
OBJECTIVE An endostatin that inhibits angiogenesis dependent tumor growth is being tested as an antitumor agent. The… Expand
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