Recombinant Human Endostatin

Known as: Endostatin, Recombinant Endostatin, rhEndostatin 
A recombinant human proteolytic fragment of the C-terminal end of type XVIII collagen. Endostatin induces microvascular endothelial cell apoptosis… (More)
National Institutes of Health

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Angiogenesis InhibitionApoptosisCOL18A1 geneEndostatin, human
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Broader (1)

Endostatins

Papers overview

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2012
2012
Recombinant Human Endostatin Normalizes Tumor Vasculature and Enhances Radiation Response in Xenografted Human Nasopharyngeal Carcinoma Models
BACKGROUND Hypoxic tumor cells can reduce the efficacy of radiation. Antiangiogenic therapy may transiently "normalize" the tumor… (More)
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2010
2010
Recombinant human endostatin improves anti-tumor efficacy of paclitaxel by normalizing tumor vasculature in Lewis lung carcinoma
Normalization of the tumor vasculature and microenvironment by several angiogenesis inhibitors has been reported. Given that… (More)
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Highly Cited
2006
Highly Cited
2006
Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors.
PURPOSE Endostatin is a 20-kd proteolytic fragment of collagen XVIII that, in preclinical studies, has been shown to have… (More)
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2006
2006
Pharmacokinetics of recombinant human endostatin in rats.
The pharmacokinetics of recombinant human endostatin (rh-Endo) has not been established in the rat, although this species of… (More)
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Highly Cited
2002
Highly Cited
2002
Phase I clinical trial of recombinant human endostatin administered as a short intravenous infusion repeated daily.
PURPOSE To perform a phase I trial of recombinant human endostatin (rhEndostatin; EntreMed, Rockville, MD) given as a daily 20… (More)
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Highly Cited
2002
Highly Cited
2002
Phase I study of recombinant human endostatin in patients with advanced solid tumors.
PURPOSE Endostatin, a 20-kd fragment of collagen XVIII, is a potent inhibitor of angiogenesis. We evaluated recombinant human… (More)
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Highly Cited
2002
Highly Cited
2002
Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin.
PURPOSE Angiogenesis is a target for the treatment of cancer and other diseases, and its complex biology suggests that… (More)
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2001
2001
Soluble recombinant endostatin purified from Escherichia coli: antiangiogenic activity and antitumor effect.
Endostatin is a potent and specific antiangiogenic protein capable of inhibiting the growth of murine and xenotransplanted human… (More)
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1999
1999
Zinc ligand-disrupted recombinant human Endostatin: Potent inhibition of tumor growth, safety and pharmacokinetic profile
Endostatin, a potent endogenous inhibitor of angiogenesis, inhibits the growth of primary tumors without induction of acquired… (More)
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1999
1999
Inhibitory effect of full-length human endostatin on in vitro angiogenesis.
Endostatin, a C-terminal product of collagen XVIII, is a very powerful angiogenesis inhibitor. In vivo experiments in mice… (More)
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