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Recombinant Human Endostatin

Known as: Endostatin, Recombinant Endostatin, rhEndostatin 
A recombinant human proteolytic fragment of the C-terminal end of type XVIII collagen. Endostatin induces microvascular endothelial cell apoptosis… Expand
National Institutes of Health

Related topics

Related topics

8 relations
Angiogenesis InhibitionApoptosisCOL18A1 geneEndostatin, human
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Broader (1)

Endostatins

Papers overview

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Highly Cited
2012
Highly Cited
2012
Recombinant Human Endostatin Normalizes Tumor Vasculature and Enhances Radiation Response in Xenografted Human Nasopharyngeal Carcinoma Models
Background Hypoxic tumor cells can reduce the efficacy of radiation. Antiangiogenic therapy may transiently “normalize” the tumor… Expand
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Highly Cited
2006
Highly Cited
2006
Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors.
PURPOSE Endostatin is a 20-kd proteolytic fragment of collagen XVIII that, in preclinical studies, has been shown to have… Expand
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Highly Cited
2004
Highly Cited
2004
Direct effects of recombinant human endostatin on tumor cell IL-8 production are associated with increased endothelial cell apoptosis in an orthotopic model of human pancreatic cancer
Purpose: Recombinant human endostatin (rhES) is an antiangiogenic agent derived from collagen XVIII which inhibits tumor growth… Expand
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Highly Cited
2003
Highly Cited
2003
Angiogenesis inhibitors target the endothelial cell cytoskeleton through altered regulation of heat shock protein 27 and cofilin.
Inhibition of angiogenesis has emerged as a key focus for the treatment of cancer, necessitating a better understanding of the… Expand
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Highly Cited
2003
Highly Cited
2003
Recombinant endostatin forms amyloid fibrils that bind and are cytotoxic to murine neuroblastoma cells in vitro
Endostatin is a fragment of collagen XVIII that acts as an endogenous inhibitor of tumor angiogenesis and tumor growth. Anti… Expand
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Highly Cited
2002
Highly Cited
2002
Phase I study of recombinant human endostatin in patients with advanced solid tumors.
PURPOSE Endostatin, a 20-kd fragment of collagen XVIII, is a potent inhibitor of angiogenesis. We evaluated recombinant human… Expand
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Highly Cited
2002
Highly Cited
2002
Phase I clinical trial of recombinant human endostatin administered as a short intravenous infusion repeated daily.
  • J. Eder, J. Supko, +17 authors D. Kufe
  • Journal of clinical oncology : official journal…
  • 2002
    • Corpus ID: 12210605
PURPOSE To perform a phase I trial of recombinant human endostatin (rhEndostatin; EntreMed, Rockville, MD) given as a daily 20… Expand
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Highly Cited
2002
Highly Cited
2002
Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin.
PURPOSE Angiogenesis is a target for the treatment of cancer and other diseases, and its complex biology suggests that… Expand
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Highly Cited
2002
Highly Cited
2002
Dephosphorylation of endothelial nitric oxide synthase contributes to the anti‐angiogenic effects of endostatin
Endostatin is an anti‐angiogenic factor that inhibits endothelial cell (EC) migration and induces EC apoptosis. Because nitric… Expand
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Highly Cited
2002
Highly Cited
2002
Treatment with the angiogenesis inhibitor endostatin: a novel therapy in rheumatoid arthritis.
OBJECTIVE An endostatin that inhibits angiogenesis dependent tumor growth is being tested as an antitumor agent. The… Expand
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