Endostatins

Known as: Endostatin, Endostatins [Chemical/Ingredient] 
Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.
National Institutes of Health

Papers overview

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Review
2006
Review
2006
The first angiogenesis inhibitors for cancer have now been approved by the F.D.A. in the U.S. and in 28 other countries… (More)
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Review
2002
Review
2002
Angiogenesis is required for invasive tumor growth and metastasis and constitutes an important point in the control of cancer… (More)
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Highly Cited
2002
Highly Cited
2002
Endostatin, a fragment of collagen XVIII, is a potent anti-angiogenic protein, but the molecular mechanism of its action is not… (More)
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Highly Cited
2001
Highly Cited
2001
Endostatin, a fragment of collagen XVIII, is a potent antagonist of angiogenesis and inhibitor of tumor growth in mouse models… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Neovascularization within the intima of human atherosclerotic lesions is well described, but its role in the… (More)
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Highly Cited
1999
Highly Cited
1999
Endostatin, a potent inhibitor of angiogenesis and tumor growth, is a COOH-terminal fragment of collagen XVIII derived through… (More)
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Highly Cited
1999
Highly Cited
1999
Endostatin is a Mr 20,000 COOH-terminal fragment of collagen XVIII that inhibits the growth of several primary tumors. We report… (More)
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Highly Cited
1999
Highly Cited
1999
Endostatin, produced as recombinant protein in human 293-EBNA cells, inhibits the migration of human umbilical vein endothelial… (More)
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Highly Cited
1998
Highly Cited
1998
The C-terminal domain NC1 of mouse collagen XVIII (38 kDa) and the shorter mouse and human endostatins (22 kDa) were prepared in… (More)
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Highly Cited
1997
Highly Cited
1997
We previously identified the angiogenesis inhibitor angiostatin. Using a similar strategy, we have identified endostatin, an… (More)
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