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Endostatins

Known as: Endostatin, Endostatins [Chemical/Ingredient] 
Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (6)

AP25 peptideEndostatin, humanLDP-endostatin N-terminal fusion proteinRecombinant Human Endostatin

Broader (2)

Angiogenesis InhibitorsAntineoplastic Agents
COL18A1 geneCOL18A1 wt AlleleCollagen Type XVIIICollagen Type XVIII, alpha1 Subunit

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
EPOX Inhibits Angiogenesis by Degradation of Mcl-1 through ERK Inactivation
Purpose: Antiangiogenic therapy is considered as an effective strategy for controlling the growth and metastasis of tumors. Among… 
Review
2006
Review
2006
Significance of vascular stabilization for tumor growth and metastasis.
2005
2005
Antiangiogenic treatment with endostatin inhibits progression of AML in vivo
Increased vessel density in the bone marrow of patients with acute myeloid leukemia as well as elevated expression of… 
2004
2004
A murine model of ex vivo angiogenesis using aortic disks grown in fibrin clot.
Highly Cited
2004
Highly Cited
2004
The Minimal Active Domain of Endostatin Is a Heparin-Binding Motif that Mediates Inhibition of Tumor Vascularization
Endostatin constitutes the COOH-terminal 20,000 Da proteolytic fragment of collagen XVIII and has been shown to possess… 
2004
2004
Rapid, in vivo, evaluation of antiangiogenic and antineoplastic gene products by nonviral transfection of tumor cells
Using a nonviral, electroporation-based gene transfection approach, we demonstrate the efficient and consistent transfection of… 
2002
2002
Inhibition of the mammary carcinoma angiogenic switch in C3(1)/SV40 transgenic mice by a mutated form of human endostatin
Cancer therapies based on the inhibition of angiogenesis by endostatin have recently been developed. We demonstrate that a… 
2002
2002
Increased levels of tissue endostatin in human malignant gliomas.
PURPOSE Malignant gliomas are typically angiogenic and express greater amounts of angiogenic factors. We examined glioma tissues… 
1999
1999
Novel glycosylated forms of human plasma endostatin and circulating endostatin-related fragments of collagen XV.
Circulating elongated forms of the angiogenesis inhibitor and potential anti-cancer drug endostatin were isolated from human… 
Review
1997
Review
1997
Recent advances in the biology and treatment of childhood acute lymphoblastic leukemia
The molecular analysis of genetic alterations in acute lymphoblastic leukemia has led to the development of molecular diagnostic… 
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