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Receptors, Proteinase-Activated

Known as: Receptors, Endopeptidase-Activated, Receptors, Protease-Activated, Endopeptidase-Activated Receptors 
A class of receptors that are activated by the action of PROTEINASES. The most notable examples are the THROMBIN RECEPTORS. The receptors contain… Expand
National Institutes of Health

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In Bloodagonistsantagonists & inhibitorsaspects of radiation effects
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Papers overview

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Highly Cited
2008
Highly Cited
2008
Cowhage-Evoked Itch Is Mediated by a Novel Cysteine Protease: A Ligand of Protease-Activated Receptors
Cowhage spicules provide an important model for histamine-independent itch. We determined that the active component of cowhage… Expand
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Review
2006
Review
2006
'Pseudopalisading' Necrosis in Glioblastoma: A Familiar Morphologic Feature That Links Vascular Pathology, Hypoxia, and Angiogenesis
Glioblastoma (GBM) is a highly malignant, rapidly progressive astrocytoma that is distinguished pathologically from lower grade… Expand
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Highly Cited
2005
Highly Cited
2005
Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets.
The roles of proteinase-activated receptors (PARs) in platelet functions other than aggregation are not well understood. Among… Expand
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Review
2005
Review
2005
CLINICAL RELEVANCE OF PROTEINASE ACTIVATED RECEPTORS (PARS) IN THE GUT
Of all the body systems, the gastrointestinal tract is the most exposed to proteinases. Under physiological conditions, digestive… Expand
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Review
2004
Review
2004
The role of protease activation of inflammation in allergic respiratory diseases.
Extracellular endogenous proteases, as well as exogenous proteases from mites and molds, react with cell-surface receptors in the… Expand
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Highly Cited
2001
Highly Cited
2001
Role of thrombin signalling in platelets in haemostasis and thrombosis
Platelets are critical in haemostasis and in arterial thrombosis, which causes heart attacks and other events triggered by… Expand
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Highly Cited
2001
Highly Cited
2001
Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity.
The bacterium Porphyromonas gingivalis is a major etiologic agent in the pathogenesis of adult periodontitis in humans. Cysteine… Expand
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Review
2000
Review
2000
Thrombin signalling and protease-activated receptors
How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one… Expand
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Highly Cited
1999
Highly Cited
1999
Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.
Because of the role of thrombin and platelets in myocardial infarction and other pathological processes, identifying and blocking… Expand
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Review
1999
Review
1999
How the protease thrombin talks to cells.
  • Shaun R Coughlin
  • Proceedings of the National Academy of Sciences…
  • 1999
    • Corpus ID: 25696381
How does a protease act like a hormone to regulate cellular functions? The coagulation protease thrombin (EC 3.4.21.5) activates… Expand
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