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Receptors, Proteinase-Activated

Known as: Receptors, Endopeptidase-Activated, Receptors, Protease-Activated, Endopeptidase-Activated Receptors 
A class of receptors that are activated by the action of PROTEINASES. The most notable examples are the THROMBIN RECEPTORS. The receptors contain… 
National Institutes of Health

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Papers overview

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Review
2017
Review
2017
What is new in the pathophysiology of acne, an overview
Acne is a chronic inflammatory disease of the pilosebaceous unit. Its pathophysiology includes hyperseborrhoea, abnormal… 
Review
2014
Review
2014
Propionibacterium acnes: an update on its role in the pathogenesis of acne
In recent years, significant progress has been made in the understanding of the pathophysiological mechanisms of acne and the… 
Review
2012
Review
2012
Targeting proteinase-activated receptors: therapeutic potential and challenges
Proteinase-activated receptors (PARs), a family of four seven-transmembrane G protein-coupled receptors, act as targets for… 
Review
2012
Review
2012
Role of G protein-coupled receptors in inflammation
AbstractG protein-coupled receptors (GPCRs) play important roles in inflammation. Inflammatory cells such as polymorphonuclear… 
Highly Cited
2008
Highly Cited
2008
Cowhage-Evoked Itch Is Mediated by a Novel Cysteine Protease: A Ligand of Protease-Activated Receptors
Cowhage spicules provide an important model for histamine-independent itch. We determined that the active component of cowhage… 
Review
2008
Review
2008
Factor Xa: at the crossroads between coagulation and signaling in physiology and disease.
Highly Cited
2004
Highly Cited
2004
Trypsin IV, a Novel Agonist of Protease-activated Receptors 2 and 4*
Certain serine proteases signal to cells by cleaving protease-activated receptors (PARs) and thereby regulate hemostasis… 
Highly Cited
2003
Highly Cited
2003
Blockade of the Thrombin Receptor Protease-Activated Receptor-1 with a Small-Molecule Antagonist Prevents Thrombus Formation and Vascular Occlusion in Nonhuman Primates
Although it is well recognized that human platelet responses to α-thrombin are mediated by the protease-activated receptors PAR-1… 
Highly Cited
2000
Highly Cited
2000
Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry.
Protease-activated receptors (PARs) mediate cell activation after proteolytic cleavage of their extracellular amino terminus… 
Highly Cited
1999
Highly Cited
1999
Thrombin and mast cell tryptase regulate guinea‐pig myenteric neurons through proteinase‐activated receptors‐1 and −2
1 Proteases regulate cells by cleaving proteinase‐activated receptors (PARs). Thrombin and trypsin cleave PAR‐1 and PAR‐2 on… 
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