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Receptors, Proteinase-Activated

Known as: Receptors, Endopeptidase-Activated, Receptors, Protease-Activated, Endopeptidase-Activated Receptors 
A class of receptors that are activated by the action of PROTEINASES. The most notable examples are the THROMBIN RECEPTORS. The receptors contain… 
National Institutes of Health

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Papers overview

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2011
2011
Tissue Factor/ FVIIa prevents the extrinsic pathway of apoptosis by regulation of the tumor suppressor Death-Associated Protein Kinase 1 (DAPK1).
Review
2008
Review
2008
Decidual Cell‐expressed Tissue Factor in Human Pregnancy and Its Involvement in Hemostasis and Preeclampsia‐related Angiogenesis
During extravascular trophoblast (EVT) invasion of the decidua, thrombin generated from decidual cell–expressed tissue factor (TF… 
2008
2008
Induction of T‐helper type 2 cytokine release and up‐regulated expression of protease‐activated receptors on mast cells by recombinant American cockroach allergen Per a 7
Background The cockroach is a major source of indoor allergens, which cause perennial rhinitis and asthma. Per a 7 is one of the… 
Highly Cited
2007
Highly Cited
2007
Src Kinase Inhibition Improves Acute Outcomes After Experimental Intracerebral Hemorrhage
Background and Purpose— The mechanisms by which intracerebral hemorrhages produce changes of blood flow and metabolism, cell… 
2007
2007
Porphyromonas gingivalis Selectively Up-Regulates the HIV-1 Coreceptor CCR5 in Oral Keratinocytes1
Primary infection of oral epithelial cells by HIV-1, if it occurs, could promote systemic infection. Most primary systemic… 
2007
2007
Activated coagulation factors in human malignant effusions and their contribution to cancer cell metastasis and therapy
Summary We have shown that the thrombin G-protein coupled receptors (GPCR) designated as protease-activated receptors (PAR-1) are… 
Review
2007
Review
2007
Snake venom proteins affecting platelets and their applications to anti-thrombotic research.
Snake venoms are very complex mixtures of biologically active proteins and peptides that may affect hemostasis in many ways, by… 
Highly Cited
2004
Highly Cited
2004
Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon
Background and aims: Protease activated receptors (PARs) have been postulated to play a role during intestinal inflammation. The… 
2004
2004
Temporal changes in pulmonary expression of key procoagulant molecules in rabbits with endotoxin-induced acute lung injury: elevated expression levels of protease-activated receptors
Summary Recently a new concept has emerged implicating thrombin signaling as the “bridge” that connects tissue damage to… 
Highly Cited
2003
Highly Cited
2003
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha.
Thrombin bound to platelets contributes to stop bleeding and, in pathological conditions, may cause vascular thrombosis. We have… 
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