Receptors, Proteinase-Activated

Known as: Receptors, Endopeptidase-Activated, Receptors, Protease-Activated, Endopeptidase-Activated Receptors 
A class of receptors that are activated by the action of PROTEINASES. The most notable examples are the THROMBIN RECEPTORS. The receptors contain… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2017
05019932017

Papers overview

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Highly Cited
2006
Highly Cited
2006
Serine proteinases like thrombin can signal to cells by the cleavage/activation of proteinase-activated receptors (PARs… (More)
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Highly Cited
2005
Highly Cited
2005
The roles of proteinase-activated receptors (PARs) in platelet functions other than aggregation are not well understood. Among… (More)
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Highly Cited
1999
Highly Cited
1999
Because of the role of thrombin and platelets in myocardial infarction and other pathological processes, identifying and blocking… (More)
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Highly Cited
1999
Highly Cited
1999
The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors for fatty acids (FAs) that regulate glucose and… (More)
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Highly Cited
1999
Highly Cited
1999
We developed a calcium signaling-based assay, using cultured human embryonic kidney cells (HEK), that evaluates simultaneously… (More)
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Highly Cited
1999
Highly Cited
1999
1. Proteases regulate cells by cleaving proteinase-activated receptors (PARs). Thrombin and trypsin cleave PAR-1 and PAR-2 on… (More)
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Highly Cited
1998
Highly Cited
1998
Protease-activated receptors 1-3 (PAR1, PAR2, and PAR3) are members of a unique G protein-coupled receptor family. They are… (More)
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Highly Cited
1997
Highly Cited
1997
Peroxisome proliferator-activated receptors (PPARs) alpha and gamma are key regulators of lipid homeostasis and are activated by… (More)
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Highly Cited
1997
Highly Cited
1997
We have used three distinct bioassay systems (rat aorta (RA) relaxation; rat gastric longitudinal muscle (LM) contraction; human… (More)
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Highly Cited
1995
Highly Cited
1995
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that regulate gene transcription in response to… (More)
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