Brain and Blood microRNA Expression Profiling of Ischemic Stroke, Intracerebral Hemorrhage, and Kainate Seizures
- Dazhi Liu, Yingfang Tian, F. Sharp
- Biology, MedicineJournal of Cerebral Blood Flow and Metabolism
- 1 January 2010
The results show the possible use of blood miRNAAs as biomarkers for brain injury; that selected blood miRNAs may correlate with miRNA changes in the brain; and that many of the mRNAs, previously shown to be regulated in brain and blood after brain injury, are likely accounted for by changes in miRNA expression.
Hemorrhagic Transformation after Ischemic Stroke in Animals and Humans
- G. Jickling, Dazhi Liu, F. Sharp
- Biology, MedicineJournal of Cerebral Blood Flow and Metabolism
- 1 February 2014
Though remarkable advances in understanding of HT have been made, additional efforts are needed to translate these discoveries to the clinic and reduce the impact of HT on patients with ischemic stroke.
Gene Expression in Peripheral Immune Cells following Cardioembolic Stroke Is Sexually Dimorphic
- B. Stamova, G. Jickling, F. Sharp
- Biology, MedicinePLoS ONE
- 18 July 2014
There are sexually dimorphic immune cell expression profiles following cardioembolic stroke and future studies are needed to confirm the findings using qRT-PCR in an independent cohort, to determine how they relate to risk and outcome, and to compare to other causes of ischemic stroke.
Targeting Neutrophils in Ischemic Stroke: Translational Insights from Experimental Studies
- G. Jickling, Dazhi Liu, B. Ander, B. Stamova, X. Zhan, F. Sharp
- Biology, MedicineJournal of Cerebral Blood Flow and Metabolism
- 25 March 2015
Several properties of neutrophil are beneficial and thus may important to preserve in patients with stroke including antimicrobial, antiinflammatory, and neuroprotective functions.
Polyunsaturated fatty acids and their effects on cardiovascular disease.
- B. Ander, C. Dupasquier, M. Prociuk, G. Pierce
- Biology, MedicineExperimental and Clinical Cardiology
- 2003
This review provides a summary of several important clinical trials and while the exact modes of action of n-3 PUFA are not known, current viewpoints regarding the mechanisms of these fatty acids on atherosclerosis, circulating lipid profile, cell membranes, cell proliferation, platelet aggregation and cardiac arrhythmias are discussed.
microRNA Expression in Peripheral Blood Cells following Acute Ischemic Stroke and Their Predicted Gene Targets
- G. Jickling, B. Ander, X. Zhan, D. Noblett, B. Stamova, Dazhi Liu
- Biology, MedicinePLoS ONE
- 9 June 2014
Several miRNA are differentially expressed in blood cells of patients with acute ischemic stroke and thus may regulate leukocyte gene expression in isChemic stroke including pathways involved in immune activation, leukocytes extravasation and thrombosis.
Effects of dietary flaxseed on vascular contractile function and atherosclerosis during prolonged hypercholesterolemia in rabbits.
- C. Dupasquier, A. Weber, G. Pierce
- Medicine, BiologyAmerican Journal of Physiology. Heart and…
- 1 December 2006
Dietary flaxseed is a valuable strategy to limit cholesterol-induced atherogenesis as well as abnormalities in endothelial-dependent vasorelaxation, however, these beneficial effects were attenuated during prolonged hypercholesterolemic conditions.
Autophagy in the brain of neonates following hypoxia–ischemia shows sex- and region-specific effects
- S. Weis, A. Toniazzo, F. Sharp
- BiologyNeuroscience
- 3 January 2014
Blood–brain barrier breakdown and repair by Src after thrombin‐induced injury
Thrombin mediates the life‐threatening cerebral edema that occurs after intracerebral hemorrhage and the mechanisms of thrombin‐induced injury to the blood-brain barrier are examined.
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