• Publications
  • Influence
Snake venom L-amino acid oxidases.
Platelets and primary haemostasis.
  • K. Clemetson
  • Biology, Medicine
    Thrombosis research
  • 1 March 2012
European Working Group on Clinical Cell Analysis: Consensus protocol for the flow cytometric characterisation of platelet function.
TLDR
Specific flow cytometry techniques for platelet analysis are recommended based on a description of the current state of flow cytometric methodology in an attempt to promote the use of these new techniques which are at present broadly evaluated for diagnostic purposes.
Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface
TLDR
Data indicate that COAT-platelets use serotonin conjugation to augment the retention of procoagulant proteins on their cell surface through an as yet unidentified serotonin receptor.
Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets.
TLDR
This study shows that platelets have functional CCR1, C CR3, CCR4, and CXCR4 chemokine receptors, which may be involved in inflammatory or allergic responses or in platelet activation in human immunodeficiency virus infection.
The Platelet Collagen Receptor Glycoprotein VI Is a Member of the Immunoglobulin Superfamily Closely Related to FcαR and the Natural Killer Receptors*
TLDR
The ability of the cloned GPVI cDNA to code for a functional platelet collagen receptor was demonstrated in the megakaryocytic cell line Dami, and it inhibited collagen-induced platelet aggregation.
Snaclecs (snake C-type lectins) that inhibit or activate platelets by binding to receptors.
  • K. Clemetson
  • Biology
    Toxicon : official journal of the International…
  • 15 December 2010
Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin.
TLDR
COAT-FV platelets may explain the unique role of alpha-granule FV and the hemostatic effectiveness of young platelets and demonstrate a new procoagulant component produced from dual stimulation of platelets with thrombin and collagen.
Snake venoms and hemostasis
TLDR
Snake venoms are complex mixtures of biologically active proteins and peptides that act selectively on different blood coagulation factors, blood cells or tissues.
Platelet Activation and Signal Transduction by Convulxin, a C-type Lectin from Crotalus durissus terrificus (Tropical Rattlesnake) Venom via the p62/GPVI Collagen Receptor*
TLDR
Results suggest that convulxin uses the p62/GPVI but not the α2β1 part of the collagen signaling pathways to activate platelets, in contrast to other venom C-type lectins acting on platelets.
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