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Receptor, PAR-1

Known as: Receptor, PAR1, Receptor, PAR 1, Protease Activated Receptor 1 
A thrombin receptor subtype that couples to HETEROTRIMERIC GTP-BINDING PROTEINS resulting in the activation of a variety of signaling mechanisms… 
National Institutes of Health

Related topics

Related topics

10 relations
F2R geneIn Bloodagonistsantagonists & inhibitors

Narrower (2)

PAR-1 receptor (1-41), humanProtease-Activated Receptor 1, human

Broader (1)

Thrombin Receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting
A novel MVB/lysosomal sorting pathway for signaling receptors bypasses the requirement for ubiquitination and ubiquitin-binding… 
Highly Cited
2009
Highly Cited
2009
Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: design and rationale for the Thrombin-Receptor Antagonist in Secondary…
Highly Cited
2006
Highly Cited
2006
Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.
Activation of latent TGF-beta by the alpha(v)beta6 integrin is a critical step in the development of acute lung injury. However… 
Highly Cited
2006
Highly Cited
2006
Thrombin Activates AMP-Activated Protein Kinase in Endothelial Cells via a Pathway Involving Ca2+/Calmodulin-Dependent Protein Kinase Kinase β
ABSTRACT AMP-activated protein kinase (AMPK) is a sensor of cellular energy state in response to metabolic stress and other… 
Highly Cited
2001
Highly Cited
2001
Thrombin Suppresses Endothelial Nitric Oxide Synthase and Upregulates Endothelin-Converting Enzyme-1 Expression by Distinct Pathways: Role of Rho/ROCK and Mitogen-Activated Protein Kinase
Abstract— An imbalance of nitric oxide and endothelin plays an important role in cardiovascular disease. Thrombin exerts profound… 
Highly Cited
2001
Highly Cited
2001
Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1.
Cell signaling by coagulation factor Xa (Xa) contributes to pro-inflammatory responses in vivo. This study characterizes the… 
Highly Cited
1998
Highly Cited
1998
Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function.
Endothelial barrier function is regulated at the cellular level by cytoskeletal-dependent anchoring and retracting forces. In the… 
Highly Cited
1998
Highly Cited
1998
Changes in the expression of protease‐activated receptor 1 and protease nexin‐1 mRNA during rat nervous system development and after nerve lesion
Thrombin causes profound metabolic and morphological changes in cultured neural cells via activation of the thrombin receptor… 
Highly Cited
1997
Highly Cited
1997
Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis.
This report shows that loss of heterozygosity at the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) locus… 
Highly Cited
1989
Highly Cited
1989
Specificity of binding of clathrin adaptors to signals on the mannose‐6‐phosphate/insulin‐like growth factor II receptor.
Adaptors mediate the interaction of clathrin with select groups of receptors. Two distinct types of adaptors, the HA‐II adaptors… 
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