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Rats, Inbred SHR

Known as: Spontaneously Hypertensive Rat, SHR Rat, Rat, SHR 
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
National Institutes of Health

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In BloodMicrobiologicalphysiological aspects

Broader (1)

Rats, Laboratory

Papers overview

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Highly Cited
2000
Highly Cited
2000
Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats.
This study was designed to test the hypothesis that stimulation of nicotinamide adenine dinucleotide/nicotinamide adenine… 
Highly Cited
1998
Highly Cited
1998
Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide.
Superoxide radical (O2-) is increased in the vessel wall of spontaneously hypertensive rats (SHR) where its blockade potentiates… 
Review
1993
Review
1993
Postexercise hypotension. Key features, mechanisms, and clinical significance.
Recent investigations have demonstrated that there is a sustained reduction in arterial blood pressure after a single bout of… 
Highly Cited
1991
Highly Cited
1991
L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats.
This study examined the contribution of nitric oxide (NO) to the susceptibility or resistance to the hypertensive effects of high… 
Highly Cited
1983
Highly Cited
1983
Role of endothelium in dilator responses of spontaneously hypertensive rat arteries.
The possible role of endothelium in the vascular responses to vasodilator drugs was studied in relation to experimental… 
Highly Cited
1981
Highly Cited
1981
Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors.
The serotonergic receptor antagonist 3-(2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl)-2,4-[1H,3H]quinazolinedione Ketanserin (R 41… 
Highly Cited
1981
Highly Cited
1981
Myosin Isoenzymic Changes in Several Models of Rat Cardiac Hypertrophy
We studied the effect of chronic mechanical overloading on the isoenzymic composition of rat cardiac myosin in several… 
Highly Cited
1978
Highly Cited
1978
Selective inhibitors of biosynthesis of aminergic neurotransmitters
ALTHOUGH the enzymatic decarboxylation of amino acids is of substantial importance to biochemistry1, there are few inhibitors of… 
Highly Cited
1976
Highly Cited
1976
Sympathetic Nerve Activity: Role in Regulation of Blood Pressure in the Spontaneously Hypertensive Rat
Sympathetic nerve activity (SNA) and high pressure baroreceptor regulation of SNA were studied in the Okamoto strain of… 
Highly Cited
1972
Highly Cited
1972
Establishment of the strokeprone spontaneously hypertensive rat (SHR)
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