Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide.

@article{Schnackenberg1998NormalizationOB,
  title={Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide.},
  author={C. Schnackenberg and W. Welch and C. Wilcox},
  journal={Hypertension},
  year={1998},
  volume={32 1},
  pages={
          59-64
        }
}
Superoxide radical (O2-) is increased in the vessel wall of spontaneously hypertensive rats (SHR) where its blockade potentiates endothelium-dependent vasodilation. The purpose of this study was to determine the role of O2- in the hypertension and renal vasoconstriction of SHR and its interaction with nitric oxide (NO). Baseline mean arterial pressure (MAP) and renal vascular resistance were markedly elevated in SHR (n=6) compared with Wistar-Kyoto rats (WKY; n=6) (145+/-4 versus 118+/-4 mmHg… Expand
Central infusion of L-arginine or superoxide dismutase does not alter arterial pressure in SHR.
Superoxide: a key player in hypertension
Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats.
Antihypertensive response to prolonged tempol in the spontaneously hypertensive rat.
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