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Rats, Inbred WKY

Known as: WISTAR KYOTO, Rats, Wistar Kyoto, Rats, WKY 
An outbred Wistar substrain derived at Kyoto school of medicine and disseminated to the NIH in 1971 and finally to Charles River in 1974. The Wistar… 
National Institutes of Health

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4 relations
Clinical Data Interchange Standards Consortium TerminologyIn BloodMicrobiologicalphysiological aspects

Papers overview

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Highly Cited
2017
Highly Cited
2017
Alterations in the gut microbiota can elicit hypertension in rats.
Gut dysbiosis has been linked to cardiovascular diseases including hypertension. We tested the hypothesis that hypertension could… 
Highly Cited
2004
Highly Cited
2004
Long-Term Clearance Kinetics of Inhaled Ultrafine Insoluble Iridium Particles from the Rat Lung, Including Transient Translocation into Secondary Organs
Recently it was speculated that ultrafine particles (UFP) may translocate from deposition sites in the lungs to systemic… 
Highly Cited
2002
Highly Cited
2002
Expression and Cellular Localization of Classic NADPH Oxidase Subunits in the Spontaneously Hypertensive Rat Kidney
Phagocytes generate superoxide anion (O2−) by a classic, 5-component NADPH oxidase. O2− contributes to hypertension in… 
Highly Cited
1998
Highly Cited
1998
Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide.
Superoxide radical (O2-) is increased in the vessel wall of spontaneously hypertensive rats (SHR) where its blockade potentiates… 
Highly Cited
1998
Highly Cited
1998
Alterations of nitric oxide synthase expression with aging and hypertension in rats.
The activity and protein expression of endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) were investigated during… 
Highly Cited
1995
Highly Cited
1995
In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats. Hydroethidine microfluorography.
The factors that predispose to the accelerated organ injury that accompanies the hypertensive syndrome have remained speculative… 
Highly Cited
1991
Highly Cited
1991
Cardioreparative Effects of Lisinopril in Rats With Genetic Hypertension and Left Ventricular Hypertrophy
BackgroundIn genetic and acquired hypertension, a structural remodeling of the nonmyocyte compartment of the myocardium… 
Highly Cited
1987
Highly Cited
1987
Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats.
Spontaneously hypertensive rats (SHR) and normotensive control, Wistar/Kyoto (WKY) rats through two generations were fed a… 
Highly Cited
1983
Highly Cited
1983
Role of endothelium in dilator responses of spontaneously hypertensive rat arteries.
The possible role of endothelium in the vascular responses to vasodilator drugs was studied in relation to experimental… 
Highly Cited
1979
Highly Cited
1979
Cardiac function and morphology with aging in the spontaneously hypertensive rat.
To determine the effects of a chronic pressure load on cardiac function and morphology, spontaneously hypertensive rats (SHR) and… 
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