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Rats, Inbred SHR

Known as: Spontaneously Hypertensive Rat, SHR Rat, Rat, SHR 
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
National Institutes of Health

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In BloodMicrobiologicalphysiological aspects

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Rats, Laboratory

Papers overview

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Highly Cited
1986
Highly Cited
1986
Lithium Infusion to Study Sodium Handling in Unanesthetized Hypertensive Rats
To investigate renal tubular handling of sodium in various types of experimental hypertension, sodium, lithium, and inulin… 
Highly Cited
1986
Highly Cited
1986
Cardiovascular effects of L-glutamate and gamma-aminobutyric acid injected into the rostral ventrolateral medulla in normotensive and spontaneously hypertensive rats.
We studied the responses to chemical stimulation of the ventrolateral medulla in pentobarbital-anaesthetized, paralyzed… 
Highly Cited
1985
Highly Cited
1985
Neuropeptide action in nucleus tractus solitarius: angiotensin specificity and hypertensive rats.
We have reported that microinjection of angiotensin II (ANG II) into the nucleus tractus solitarius of urethan-anesthetized… 
Highly Cited
1984
Highly Cited
1984
Evidence for an intestinal mechanism in hypercalciuria of spontaneously hypertensive rats.
To define the mechanism for the hypercalciuria in spontaneously hypertensive rats (SHR), Ca clearance was evaluated in fasted 23… 
Review
1983
Review
1983
Do resistance vessel abnormalities contribute to the elevated blood pressure of spontaneously-hypertensive rats? A review of some of the evidence.
This review summarizes some of the evidence pointing to the existence of vascular abnormalities in the spontaneously hypertensive… 
1983
1983
Factors involved in the antihypertensive action of calcium antagonists.
The main mechanism underlying the antihypertensive action of calcium antagonists is believed to be the vasodilation of peripheral… 
Highly Cited
1981
Highly Cited
1981
Hypersensitivity of spontaneously hypertensive rats (SHR) to heat, ether, and immobilization.
The responses to immobilization, ether, and heat of spontaneously hypertensive rats (SHR) and normotensive Sprague-Dawley rats (S… 
Highly Cited
1980
Highly Cited
1980
The concentrations of ionic and total calcium in plasma of the spontaneously hypertensive rat.
The levels of ionic calcium in whole blood obtained from male spontaneously hypertensive rats (SHR) were slightly decreased… 
Highly Cited
1975
Highly Cited
1975
Enhancement of hypothalamic pressor responses in spontaneously hypertensive rats.
The cardiovascular effects of stimulating the posterior hypothalamus electrically were recorded in awake rats to permit in situ… 
1970
1970
Renal vascular resistance in spontaneously hypertensive rats.
The renal vascular beds of one spontaneously hypertensive rat (SHR) and one matched normotensive control rat (NCR) were perfused…