Rats, Inbred SHR

Known as: Spontaneously Hypertensive Rat, SHR Rat, Rat, SHR 
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
National Institutes of Health

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Highly Cited
2001
Highly Cited
2001
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) significantly reduce cardiovascular mortality… (More)
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Review
2000
Review
2000
A good model of a disorder is one that: (a) mimics, although in a simpler form than the full-blown clinical case, the… (More)
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Highly Cited
2000
Highly Cited
2000
In hypertension arterial wall properties do not necessarily depend on increased blood pressure alone. The present study… (More)
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Highly Cited
2000
Highly Cited
2000
The cytochrome P450-derived epoxyeicosatrienoic acids (EETs) have potent effects on renal vascular reactivity and tubular sodium… (More)
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Highly Cited
1999
Highly Cited
1999
The human insulin-resistance syndromes, type 2 diabetes, obesity, combined hyperlipidaemia and essential hypertension, are… (More)
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Highly Cited
1998
Highly Cited
1998
Superoxide radical (O2-) is increased in the vessel wall of spontaneously hypertensive rats (SHR) where its blockade potentiates… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND AND PURPOSE Tumor necrosis factor-alpha (TNF-alpha) is a pleiotropic cytokine that rapidly upregulates in the brain… (More)
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Highly Cited
1991
Highly Cited
1991
Although active oxygen species play important roles in the pathogenesis of various diseases, the molecular mechanism for oxygen… (More)
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Highly Cited
1986
Highly Cited
1986
To study the mechanism of decreased endothelium-dependent relaxations in spontaneously hypertensive rats (SHR), rings of thoracic… (More)
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Highly Cited
1974
Highly Cited
1974
Ventricular weight in spontaneously hypertensive rats (F26 generation, Okamoto-Aoki strain) was significantly higher (P < 0.001… (More)
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