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Rats, Inbred SHR

Known as: Spontaneously Hypertensive Rat, SHR Rat, Rat, SHR 
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
National Institutes of Health

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In BloodMicrobiologicalphysiological aspects

Broader (1)

Rats, Laboratory

Papers overview

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Highly Cited
2015
Highly Cited
2015
Gut Dysbiosis Is Linked to Hypertension
Emerging evidence suggests that gut microbiota is critical in the maintenance of physiological homeostasis. This study was… 
Highly Cited
2008
Highly Cited
2008
Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137): New Insights Into the Biology of Hydrogen Sulfide
Background— The potential biological significance of hydrogen sulfide (H2S) has attracted growing interest in recent years. The… 
Review
2001
Review
2001
Gender Differences in the Regulation of Blood Pressure
Abstract—Men are at greater risk for cardiovascular and renal disease than are age-matched, premenopausal women. Recent studies… 
Highly Cited
1999
Highly Cited
1999
Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
The human insulin-resistance syndromes, type 2 diabetes, obesity, combined hyperlipidaemia and essential hypertension, are… 
Highly Cited
1994
Highly Cited
1994
Tumor necrosis factor-alpha expression in ischemic neurons.
BACKGROUND AND PURPOSE Tumor necrosis factor-alpha (TNF-alpha) is a cytokine with diverse proinflammatory actions, including… 
Highly Cited
1991
Highly Cited
1991
Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat
Highly Cited
1991
Highly Cited
1991
Does superoxide underlie the pathogenesis of hypertension?
Although active oxygen species play important roles in the pathogenesis of various diseases, the molecular mechanism for oxygen… 
Highly Cited
1991
Highly Cited
1991
Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats
The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension… 
Highly Cited
1986
Highly Cited
1986
Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.
To study the mechanism of decreased endothelium-dependent relaxations in spontaneously hypertensive rats (SHR), rings of thoracic… 
Highly Cited
1963
Highly Cited
1963
Development of a strain of spontaneously hypertensive rats.
A male rat with spontaneously high systolic blood pressures of 150 to 175 mmHg persisting for more than one month and a female… 
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