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Rats, Inbred SHR

Known as: Spontaneously Hypertensive Rat, SHR Rat, Rat, SHR 
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Emerging evidence suggests that gut microbiota is critical in the maintenance of physiological homeostasis. This study was… 
Highly Cited
2008
Highly Cited
2008
Background— The potential biological significance of hydrogen sulfide (H2S) has attracted growing interest in recent years. The… 
Review
2001
Review
2001
Abstract—Men are at greater risk for cardiovascular and renal disease than are age-matched, premenopausal women. Recent studies… 
Highly Cited
1999
Highly Cited
1999
The human insulin-resistance syndromes, type 2 diabetes, obesity, combined hyperlipidaemia and essential hypertension, are… 
Highly Cited
1994
Highly Cited
1994
BACKGROUND AND PURPOSE Tumor necrosis factor-alpha (TNF-alpha) is a cytokine with diverse proinflammatory actions, including… 
Highly Cited
1991
Highly Cited
1991
Although active oxygen species play important roles in the pathogenesis of various diseases, the molecular mechanism for oxygen… 
Highly Cited
1991
Highly Cited
1991
The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension… 
Highly Cited
1986
Highly Cited
1986
To study the mechanism of decreased endothelium-dependent relaxations in spontaneously hypertensive rats (SHR), rings of thoracic… 
Highly Cited
1963
Highly Cited
1963
A male rat with spontaneously high systolic blood pressures of 150 to 175 mmHg persisting for more than one month and a female…