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Rats, Transgenic

Known as: Rat, Transgenic, Transgenic Rat, Transgenic Rats 
Laboratory rats that have been produced from a genetically manipulated rat EGG or rat EMBRYO, MAMMALIAN. They contain genes from another species.
National Institutes of Health

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3 relations
In BloodMicrobiologicalphysiological aspects

Papers overview

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Highly Cited
2012
Highly Cited
2012
Mitochondrial Dynamics and Bioenergetic Dysfunction Is Associated with Synaptic Alterations in Mutant SOD1 Motor Neurons
Mutations in Cu,Zn superoxide dismutase (SOD1) cause familial amyotrophic lateral sclerosis (FALS), a rapidly fatal motor neuron… 
Highly Cited
2008
Highly Cited
2008
A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment
Highly Cited
2007
Highly Cited
2007
XIAP Protection of Photoreceptors in Animal Models of Retinitis Pigmentosa
Background Retinitis pigmentosa (RP) is a blinding genetic disorder that is caused by the death of photoreceptors in the outer… 
Highly Cited
2006
Highly Cited
2006
Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats.
The generation of the Lew.Tg(mRen2) congenic hypertensive rat strain, developed through a backcross of the hypertensive (mRen2)27… 
Highly Cited
2006
Highly Cited
2006
Additional human beta2-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats.
OBJECTIVE Ankylosing spondylitis and related spondylarthritides are associated with HLA-B27, and also with intestinal… 
Highly Cited
2005
Highly Cited
2005
Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity.
Inflammation is now recognized as a key component in a number of diseases such as atherosclerosis, rheumatoid arthritis, and… 
Highly Cited
2001
Highly Cited
2001
Migration, integration, and differentiation of hippocampus-derived neurosphere cells after transplantation into injured rat spinal cord
Highly Cited
2000
Highly Cited
2000
Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression.
Exogenous neuropeptide Y (NPY) reduces experimental anxiety in a wide range of animal models. The generation of an NPY-transgenic… 
Highly Cited
1996
Highly Cited
1996
Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver.
We have developed a transgenic animal model to investigate the effects of overexpression of rat prorenin on the cardiovascular… 
Highly Cited
1992
Highly Cited
1992
Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes.
The renin-angiotensin system (RAS) is the most important regulatory system of electrolyte homeostasis and blood pressure. We… 
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