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Characterization of the junctional face membrane from terminal cisternae of sarcoplasmic reticulum
TLDR
The JFM, which is involved in junctional association with transverse tubule and likely in the Ca2+ release process in excitation-contraction coupling, is now available in the test tube. Expand
Molecular cloning and characterization of the ryanodine receptor/junctional channel complex cDNA from skeletal muscle sarcoplasmic reticulum.
TLDR
The ryanodine receptor of sarcoplasmic reticulum has been isolated and found to be morphologically identical to the foot structure, which is involved in the junctional association of terminal cisternae with the transverse tubule. Expand
Isolation and characterization of the inositol trisphosphate receptor from smooth muscle.
TLDR
The isolation of an IP3 receptor from smooth muscle is similar to the ryanodine receptor with regard to its large size and fourfold symmetry, albeit distinct with regards to appearance, protomer size, and ligand binding. Expand
Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity.
TLDR
This pathway-selective ligand does not promote the classic actions of estrogens such as stimulation of uterine proliferation or ER-mediated gene expression, but is a potent antiinflammatory agent, as demonstrated in the HLA-B27 transgenic rat model of inflammatory bowel disease. Expand
Purified IP3 receptor from smooth muscle forms an IP3 gated and heparin sensitive Ca2+ channel in planar bilayers.
TLDR
The purified IP3 receptor of aortic smooth muscle forms a channel with functional properties characteristic of IP3 triggered Ca2+ release, characterized by fast transitions between predominantly non-resolved sublevels. Expand
Cryo-EM of the native structure of the calcium release channel/ryanodine receptor from sarcoplasmic reticulum.
TLDR
The native structure of the calcium release channel from rabbit skeletal muscle has been analyzed in two dimensions from electron micrographs of frozen hydrated specimens and features seen in the three-dimensional reconstruction of the negatively stained channel can be identified in the projection of the unstained receptor. Expand
Antimycins, inhibitors of ATP-citrate lyase, from a Streptomyces sp.
TLDR
A related group of compounds belonging to the antimycin class of antibiotics was found in culture broth produced by a Streptomyces species and the structures of the new antimycins A7 and A8 were determined by spectroscopic analyses. Expand
Monomers of the Neurospora plasma membrane H+-ATPase catalyze efficient proton translocation.
TLDR
The results thus clearly demonstrate that 105,000-dalton monomers of the Neurospora plasma membrane H+-ATPase can catalyze efficient ATP hydrolysis-driven proton translocation. Expand
Inactivation of sarcoplasmic reticulum (Ca2+ + Mg2+)-ATPase by N-cyclohexyl-N'-(4-dimethylamino-alpha-naphthyl)carbodiimide.
TLDR
The synthesis and characterisation of N-cyclohexyl-N'-(4-dimethylamino-alpha-naphthyl)carbodiimide is described and it is concluded that NCD-4 has modified a carboxylate group located in or near the Ca2+-binding sites of the ATPase. Expand
A hexameric form of the Neurospora crassa plasma membrane H+-ATPase.
TLDR
Treatment of the particles isolated in the presence of Tween 20 with glutaraldehyde progressively yields dimers, trimers, tetramers, pentamers, and hexamers of the 105,000-Da monomer, with the expected precursor-product relationships, but no species larger than a hexamer is formed. Expand
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