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Rat Insulinoma

An insulin-producing neuroendocrine tumor arising from beta cells of the rat pancreas.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired…
Both peroxisome proliferator-activated receptor-alpha (PPARalpha) and pancreatic/duodenal homeobox-1 (PDX-1) have been reported… 
Highly Cited
1998
Highly Cited
1998
Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells
Summary Neuropeptide Y (NPY) has been shown to inhibit insulin secretion from the islets of Langerhans. We show that insulin… 
Highly Cited
1994
Highly Cited
1994
Mechanisms of cytokine-induced destruction of rat insulinoma cells: the role of nitric oxide.
Cytokines produced by immune system cells infiltrating pancreatic islets are candidate mediators of islet beta-cell destruction… 
1994
1994
Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line Rinm5F; sequencing a rat type II interleukin-1 receptor cDNA.
The insulin secreting rat Rinm5F cells are often used to study the cytotoxic actions of interleukin-1 (IL-1) on pancreatic beta… 
Highly Cited
1993
Highly Cited
1993
Amino-terminal parathyroid hormone-related protein: specific binding and cytosolic calcium responses in rat insulinoma cells.
PTH-related protein (PTHrP), originally identified through its causative role in human humoral hypercalcemia of malignancy, is… 
Highly Cited
1991
Highly Cited
1991
Growth hormone action in rat insulinoma cells expressing truncated growth hormone receptors.
Transfection of the insulin-producing rat islet tumor cell line RIN-5AH with a full length cDNA of the rat hepatic growth hormone… 
Highly Cited
1990
Highly Cited
1990
Introduction of exogenous growth hormone receptors augments growth hormone-responsive insulin biosynthesis in rat insulinoma cells.
The stimulation of insulin biosynthesis in the pancreatic insulinoma cell line RIN5-AH by growth hormone (GH) is initiated by GH… 
Highly Cited
1989
Highly Cited
1989
Characterization of the receptor for glucagon-like peptide-1(7-36)amide on plasma membranes from rat insulinoma-derived cells by covalent cross-linking.
125I-Labelled glucagon-like peptide-1(7-36)amide was cross-linked to a specific binding protein in plasma membranes prepared from… 
Highly Cited
1987
Highly Cited
1987
Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines.
The developmental origin of the four phenotypically distinct hormone-producing islet cells (insulin, glucagon, somatostatin… 
1985
1985
Growth hormone binding to specific receptors stimulates growth and function of cloned insulin-producing rat insulinoma RIN-5AH cells.
Binding of 125I-labeled human GH (hGH) to a cloned rat insulin-producing cell line RIN-5AH in monolayer culture was studied along… 
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