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The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates
The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV- 1 isolates. Expand
Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
It is shown that functional loss of GD-linked glucocerebrosidase in primary cultures or human iPS neurons compromises lysosomal protein degradation, causes accumulation of α-synuclein (α-syn), and results in neurotoxicity through aggregation-dependent mechanisms, suggesting that GCase depletion contributes to the pathogenesis of sporadic synucleinopathies. Expand
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
It is found that CRISPR/Cas9 could effectively cleave the endogenous β-globin gene (HBB), however, the efficiency of homologous recombination directed repair (HDR) of HBB was low and the edited embryos were mosaic. Expand
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
CHI3L1 is a susceptibility gene for asthma, bronchial hyperresponsiveness, and reduced lung function, and elevated circulating YKL-40 levels are a biomarker for asthma and decline in lung function. Expand
Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection
Two orphan seven-transmembrane segment receptors, gpr1 and gpr15, serve as coreceptors for SIV, and are expressed in human alveolar macrophages, and may contribute to an understanding of viral variation and pathogenesis. Expand
Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein Complex
The structure of the nsp16/nsp10 interaction interface shows that nsp10 may stabilize the SAM-binding pocket and extend the substrate RNA-binding groove of nsp15, consistent with the findings in biochemical assays, and suggest that nSp16/Nsp10 interface may represent a better drug target than the viral MTase active site for developing highly specific anti-coronavirus drugs. Expand
Problematic Internet use in Chinese adolescents and its relation to psychosomatic symptoms and life satisfaction
PIU is common among Chinese students, and PIU was significantly associated with psychosomatic symptoms and life satisfaction, and effective measures are needed to prevent the spread of this problem. Expand
A Valid Matérn Class of Cross-Covariance Functions for Multivariate Random Fields With Any Number of Components
We introduce a valid parametric family of cross-covariance functions for multivariate spatial random fields where each component has a covariance function from a well-celebrated Matérn class. UnlikeExpand
Asynchronous P300 BCI: SSVEP-based control state detection
An asynchronous hybrid brain-computer interface (BCI) system combining the P300 and steady-state visually evoked potentials (SSVEP) paradigms is introduced and is shown to achieve fast and accurate control state detection without significantly compromising the performance. Expand
Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members Published, JLR Papers in Press, September 8, 2005. DOI 10.1194/jlr.M500290-JLR200
The data support distinct functions for Adiponutrin and Desnutrin/ATGL and raise the possibility that GS2 may contribute significantly to lipolysis in human adipose tissue. Expand