• Publications
  • Influence
The role of inflammation in epilepsy
This work focuses on the rapidly growing body of evidence that supports the involvement of inflammatory mediators—released by brain cells and peripheral immune cells—in both the origin of individual seizures and the epileptogenic process. Expand
Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases
The data suggest that IL-1β increases NMDA receptor function through activation of tyrosine kinases and subsequent NR2A/B subunit phosphorylation, which may contribute to glutamate-mediated neurodegeneration. Expand
Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice.
IL-1beta and its endogenous receptor antagonist (IL-1Ra) are rapidly induced by seizures in the rodent hippocampus. Exogenously applied IL-1beta prolongs seizures in an IL-1R type I-mediated manner.Expand
Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice.
This work describes the derivation and characterization of mice deficient in expression of the type I IL-1R (IL-1RI), demonstrating that the IL- 1RI is essential for all IL-2-mediated signaling events examined, and that both IL-4alpha and IL-3beta are critical to the animals' response to injury and infection. Expand
A Specific Role for NR2A-Containing NMDA Receptors in the Maintenance of Parvalbumin and GAD67 Immunoreactivity in Cultured Interneurons
The results suggest that the activity of NR2A-containing NMDA receptors play a pivotal role in the maintenance of the GABAergic function of PV interneurons. Expand
A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus.
It is demonstrated that 14 days of FLX treatment up-regulated galanin mRNA levels by 100% and GalR2-binding sites by 50%, in the rat dorsal raphe nucleus, where galAnin coexists with serotonin, underlining the connection between activation of the galan inergic system and antidepressant action of various clinically proven treatments. Expand
Interleukin‐1β contributes to the generation of experimental febrile seizures
It is indicated that IL‐1β signaling contributes critically to fever‐induced hyperexcitability underlying FS, constituting a potential target for their prevention. Expand
A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta.
Results indicate that the proconvulsive actions of IL-1beta depend on the activation of a sphingomyelinase- and Src-family of kinases-dependent pathway in the hippocampus which leads to the phosphorylation of the NR2B subunit, thus highlighting a novel, non-transcriptional mechanism underlying seizure exacerbation in inflammatory conditions. Expand
Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist.
It can be concluded that blockage ofIL-1 signaling by elevated levels of IL-1ra has a neuroprotective effect, in agreement with previous reports, and that central overexpression of IL -1ra results in delayed proinflammatory cytokine induction and improved neurological recovery after traumatic brain injury. Expand
Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice
It is suggested that central IL- 6 is a necessary component of the fever response to both endogenous (IL-1 beta) and exogenous (LPS) pyrogens in mice and that IL-6 acts downstream from both peripheral andcentral IL- 1 beta. Expand