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Ras Signaling Pathway

Ras activates many signaling cascades. Here we illustrate some of the well-characterized cascades in a generic compilation of effector molecules. The… Expand
National Institutes of Health

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AKT1 wt AlleleBAD wt AlleleBCL-XL ProteinBCL2L1 wt Allele
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Papers overview

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Highly Cited
2012
Highly Cited
2012
Activation of Ras Signaling Pathway by 8-Oxoguanine DNA Glycosylase Bound to Its Excision Product, 8-Oxoguanine*
Background: 8-Oxo-7,8-dihydroguanine (8-oxoG) is an abundant DNA base lesion repaired by 8-oxoguanine glycosylase (OGG1) via the… Expand
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Review
2006
Review
2006
An unexpected new role of mutant Ras: perturbation of human embryonic development
The Ras signaling pathway controls important cellular responses to growth factors, and somatic mutations in RAS genes and other… Expand
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2004
2004
NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection.
ATP-sensitive potassium (K(ATP)) channels regulate insulin release, vascular tone, and neuronal excitability. Whether these… Expand
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2003
2003
Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequence.
Connexin 43 (Cx43) is essential for survival and is tightly regulated at the transcriptional and post-transcriptional levels. A… Expand
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Highly Cited
1999
Highly Cited
1999
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation.
Components of the ras signaling pathway contribute to activation of cellular p53. In MCF-7 cells, p38 kinase activated p53 more… Expand
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1995
1995
Cell fate control in the Drosophila retina by the orphan receptor seven-up: its role in the decisions mediated by the ras signaling pathway.
Drosophila seven-up is an orphan receptor of the steroid receptor family that is required to specify photoreceptor neuron… Expand
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Highly Cited
1994
Highly Cited
1994
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
Activation of growth factor receptors results in tyrosine autophosphorylation and recruitment of SH2 domain-containing effectors… Expand
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Highly Cited
1994
Highly Cited
1994
The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins.
The Caenorhabditis elegans locus lin-15 negatively regulates an intercellular signaling process that induces formation of the… Expand
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Highly Cited
1994
Highly Cited
1994
The UV response involving the ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals
UV irradiation of mammalian cells activates AP-1 through a Ras-dependent pathway, independently of DNA damage. We show that the… Expand
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1994
1994
Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway.
Activation of monocytes by bacterial lipopolysaccharides (LPSs) is a central component in the pathogenesis of septic shock… Expand
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