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Gene expression profiles in breast tumors regarding the presence or absence of estrogen and progesterone receptors
Estrogen acts via its receptor (ER) to stimulate cell growth and differentiation in the mammary gland. ER and progesterone receptor (PR), which is regulated by estrogen via ER, have been used asExpand
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Triiodothyronine mimics the effects of estrogen in breast cancer cell lines
MCF-7 (estrogen receptor positive--ER+) and MDA-MB-231 (estrogen receptor negative--ER-) are human breast cancer cell lines which express functional thyroid hormone receptors (c-erb A alpha1 andExpand
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Concomitant expression of epithelial-mesenchymal transition biomarkers in breast ductal carcinoma: association with progression.
Epithelial to mesenchymal transition (EMT) is a process implicated in cancer progression in which the underlying cellular changes have been identified mainly using in vitro models. We determined theExpand
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Prognostic significance of CD24 and claudin-7 immunoexpression in ductal invasive breast cancer.
This study aimed to identify the CD24 and CD44 immunophenotypes within invasive ductal breast carcinoma (IDC) subgroups defined by immunohistochesmistry markers and toExpand
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Expression of growth factors, proto-oncogenes, and p53 in nasopharyngeal angiofibromas.
Biopsies from 25 juvenile nasopharyngeal angiofibromas (JNAs) and respective normal inferior turbinates were examined and compared. The expression patterns of the messenger RNAs (mRNAs) for variousExpand
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Transforming growth factor β1, urokinase‐type plasminogen activator and plasminogen activator inhibitor‐1 mRNA expression in head and neck squamous carcinoma and normal adjacent mucosa
A balance between urokinase‐type plasminogen activator (uPA) and its main inhibitor type‐1 (PAI‐1) appears to be important for cancer invasive behavior. Since uPA/PAI‐1 system seems to be regulatedExpand
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Lipid raft disruption by docosahexaenoic acid induces apoptosis in transformed human mammary luminal epithelial cells harboring HER-2 overexpression.
In HER-2-overexpressing breast cells, HER-2 receptors exist on the cell surface as monomers, homodimers and heterodimers. For signal activation and transduction to occur, HER-2 must be localized toExpand
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Comprehensive Analysis of BRCA1, BRCA2 and TP53 Germline Mutation and Tumor Characterization: A Portrait of Early-Onset Breast Cancer in Brazil
Germline mutations in BRCA1, BRCA2 and TP53 genes have been identified as one of the most important disease-causing issues in young breast cancer patients worldwide. The specific defective biologicalExpand
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Gene Expression Profile Associated with Response to Doxorubicin-Based Therapy in Breast Cancer
Purpose: This study was designed to identify genes that could predict response to doxorubicin-based primary chemotherapy in breast cancer patients. Experimental Design: Biopsy samples were obtainedExpand
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Down-regulation of PHLDA1 gene expression is associated with breast cancer progression
In a previous study, using differential display reverse transcriptase-PCR (DDRT-PCR) we showed that down-regulation of the PHLDA1 (pleckstrin homology-like domain, family A, member 1; also namedExpand
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