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RYR1 gene

Known as: PPP1R137, protein phosphatase 1, regulatory subunit 137, RYR1 
National Institutes of Health

Related topics

Related topics

2 relations
Ryanodine Receptor 1ryanodine receptor complex location

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice
Rationale: Abnormal calcium release from sarcoplasmic reticulum (SR) is considered an important trigger of atrial fibrillation… 
Highly Cited
2009
Highly Cited
2009
Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes
We have applied an optical super-resolution technique based on single-molecule localization to examine the peripheral… 
Highly Cited
2009
Highly Cited
2009
Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress and β-Cell Death
OBJECTIVE—Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of diabetes, but the roles of specific ER Ca2… 
Highly Cited
2007
Highly Cited
2007
The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes
cAMP is a powerful second messenger whose known general effector is protein kinase A (PKA). The identification of a cAMP binding… 
Highly Cited
2006
Highly Cited
2006
Ca2+/Calmodulin-Dependent Protein Kinase II Phosphorylation of Ryanodine Receptor Does Affect Calcium Sparks in Mouse Ventricular Myocytes
Previous studies in transgenic mice and with isolated ryanodine receptors (RyR) have indicated that Ca2+-calmodulin-dependent… 
Highly Cited
2002
Highly Cited
2002
FKBP12.6-Mediated Stabilization of Calcium-Release Channel (Ryanodine Receptor) as a Novel Therapeutic Strategy Against Heart Failure
Background—The development of heart failure is tightly correlated with a decrease in the stoichiometric ratio for FKBP12.6… 
Highly Cited
2000
Highly Cited
2000
Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical Neurons*
Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. PS1… 
Highly Cited
2000
Highly Cited
2000
Altered Stoichiometry of FKBP12.6 Versus Ryanodine Receptor as a Cause of Abnormal Ca2 Leak Through Ryanodine Receptor in Heart Failure
BackgroundIn the pathogenesis of cardiac dysfunction in heart failure, a decrease in the activity of the sarcoplasmic reticulum… 
Highly Cited
1995
Highly Cited
1995
Differential regulation of two types of intracellular calcium release channels during end-stage heart failure.
The molecular basis of human heart failure is unknown. Alterations in calcium homeostasis have been observed in failing human… 
Highly Cited
1995
Highly Cited
1995
Characterization of an Exchange Reaction between Soluble FKBP-12 and the FKBP·Ryanodine Receptor Complex
FKBP-12 (FKBP), the soluble receptor for the immunosuppresant drug FK-506, is tightly bound to the calcium release channel (CRC… 
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