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RXFP2 gene

Known as: relaxin/insulin like family peptide receptor 2, LGR8, RXFP2 
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane.
Insulin-like 3 (INSL3) hormone plays a crucial role in testicular descent during embryonic development. Genetic ablation of Insl3… 
Review
2006
Review
2006
Relaxin-a pleiotropic hormone and its emerging role for experimental and clinical therapeutics.
Highly Cited
2006
Highly Cited
2006
Expression of the Insulin-Like Peptide 3 (INSL3) Hormone-Receptor (LGR8) System in the Testis1
Abstract The new peptide hormone insulin-like peptide 3 (INSL3) is a member of the insulin-relaxin family, yet, unlike insulin… 
Highly Cited
2005
Highly Cited
2005
Characterization of the Rat INSL3 Receptor
Abstract: Human LGR8, initially discovered as a low‐affinity relaxin receptor, has now been characterized as the INSL3 receptor… 
Highly Cited
2005
Highly Cited
2005
Multiple Binding Sites Revealed by Interaction of Relaxin Family Peptides with Native and Chimeric Relaxin Family Peptide Receptors 1 and 2 (LGR7 and LGR8)
Relaxin family peptide 1 (RXFP1) receptor (LGR7) and RXFP2 receptor (LGR8) were recently identified as the receptor targets for… 
Highly Cited
2005
Highly Cited
2005
LGR8 Signal Activation by the Relaxin-like Factor*
The relaxin-like factor (RLF) is thought to be responsible for the intra-abdominal migration of the testis during mammalian… 
Highly Cited
2004
Highly Cited
2004
Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist
The insulin‐like peptide relaxin is a central hormone of pregnancy, but it also produces anti‐ fibrotic, myocardial, renal… 
Highly Cited
2003
Highly Cited
2003
H3 Relaxin Is a Specific Ligand for LGR7 and Activates the Receptor by Interacting with Both the Ectodomain and the Exoloop 2*
Leucine-rich repeat-containing, G protein-coupled receptors (LGRs) represent a unique subgroup of G protein-coupled receptors… 
Review
2003
Review
2003
Relaxin‐like peptides in cancer
The members of the relaxin‐like hormone family, relaxin and INSL3, also known as relaxin‐like factor (RLF) or Leydig cell‐derived… 
Highly Cited
2003
Highly Cited
2003
Phosphoinositide 3-kinase activity is required for biphasic stimulation of cyclic adenosine 3',5'-monophosphate by relaxin.
The G protein-coupled receptors LGR7 and LGR8 have recently been identified as the primary receptors for the polypeptide hormone… 
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