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Cancer stem cell markers in common cancers - therapeutic implications.
Molecular and genetic regulation of testis descent and external genitalia development.
Stimulation of monokine production by lipoteichoic acids
Some species of LTAs are identified as inducers of monokine production in human monocytes, and kinetics of IL-1 beta and tumor necrosis factor alpha release elicited by LTAs closely resembled those observed following lipopolysaccharide application.
Molecular interactions of the aryl hydrocarbon receptor and its biological and toxicological relevance for reproduction.
The major types of molecular cross-talks that have been identified for the AhR and linked cell signaling pathways and that are relevant for the understanding of the role of this transcription factor in female reproduction are summarized.
Expression of protamine-1 and -2 mRNA during human spermiogenesis.
- K. Steger, K. Pauls, T. Klonisch, F. Franke, M. Bergmann
- BiologyMolecular human reproduction
- 1 March 2000
The combination of UV-LACP and non-radioactive in-situ hybridization appear to be a suitable approach for the study of cell-specific and stage-specific gene expression during spermiogenesis.
An investigation of the effects of endometriosis on the proteome of human eutopic endometrium: A heterogeneous tissue with a complex disease
2‐DE gel analysis and mass spectroscopic protein identification are suitable for the identification of proteins with candidate associations with endometriosis and should be used on a larger scale to identify endometiosis‐related proteins, thus improving the understanding of this complex disease.
Brevinin-2R1 semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway
- S. Ghavami, A. Asoodeh, M. Los
- Biology, ChemistryJournal of cellular and molecular medicine
- 1 June 2008
Results show that Brevinin‐2R activates the lysosomalmitochondrial death pathway, and involves autophagy‐like cell death, as well as interacts with both early and late endosomes.
S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2.
INSL5-deficient mice display an alteration in glucose homeostasis and an impaired fertility.
The potential role of INSL5 signaling in the regulation of insulin secretion and β-cell homeostasis is suggested.
Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development
- Mayur V. Jain, Anna M. Paczulla, Marek J. Łos
- BiologyJournal of cellular and molecular medicine
- 1 January 2013
This review extends the analysis of cell death beyond apoptosis to include signalling pathways governing autophagy and necrosis and highlights stress‐induced cell senescence that plays a role not only in organismal ageing but also offers the development of novel anticancer strategies.