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Relaxin family peptides and their receptors.
There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has many roles in female and male reproduction, as a neuropeptide in the central nervous system, as aExpand
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Human Relaxin Gene 3 (H3) and the Equivalent Mouse Relaxin (M3) Gene
We have identified a novel human relaxin gene, designated H3 relaxin, and an equivalent relaxin gene in the mouse from the Celera Genomics data base. Both genes encode a putative prohormone sequenceExpand
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International Union of Pharmacology LVII: Recommendations for the Nomenclature of Receptors for Relaxin Family Peptides
Although the hormone relaxin was discovered 80 years ago, only in the past 5 years have the receptors for relaxin and three other receptors that respond to related peptides been identified with allExpand
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Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2
The hormone relaxin inhibits renal myofibroblast differentiation by interfering with TGF‐β1/ Smad2 signaling. However, the pathways involved in the relaxin‐TGF‐β1/Smad2 interaction remain unknown.Expand
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Excitatory amino acid projections to the nucleus accumbens septi in the rat: A retrograde transport study utilizingd[3H]aspartate and [3H]GABA
Afferents to the nucleus accumbens septi utilizing glutamate or aspartate have been investigated in the rat by autoradiography following injection and retrograde transport of D[3H]aspartate. ParallelExpand
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Antidepressant binding sites in brain: autoradiographic comparison of [3H]paroxetine and [3H]imipramine localization and relationship to serotonin transporter.
Binding of two different antidepressant drugs, [3H]paroxetine and [3H]imipramine in 30 rat brain regions was visualized, compared and quantified by means of autoradiography and densitometry. SpecificExpand
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Relaxin Family Peptide Receptors RXFP1 and RXFP2 Modulate cAMP Signaling by Distinct Mechanisms
Two orphan leucine-rich repeat-containing G protein-coupled receptors were recently identified as targets for the relaxin family peptides relaxin and insulin-like peptide (INSL) 3. Human gene 2Expand
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The rush to adrenaline: drugs in sport acting on the β‐adrenergic system
Athletes attempt to improve performance with drugs that act on the β‐adrenergic system directly or indirectly. Of three β‐adrenoceptor (AR) subtypes, the β2‐AR is the main target in sport; they haveExpand
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Relaxin Family Peptide Receptors – former orphans reunite with their parent ligands to activate multiple signalling pathways
The relaxin family peptides, although structurally closely related to insulin, act on a group of four G protein‐coupled receptors now known as Relaxin Family Peptide (RXFP) Receptors. TheExpand
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Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening
The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of insulin secretion and a major therapeutic target for treatment of diabetes. However, GLP-1 receptor function is complex, withExpand
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