Complexity and diversity of mammalian adenylyl cyclases.
- R. Sunahara, C. Dessauer, A. Gilman
- BiologyAnnual Review of Pharmacology and Toxicology
- 1996
The discovery of new isoforms of mammalian adenylyl cyclase has revealed unanticipated mechanisms of regulation, including activation or inhibition by the G-protein beta gamma subunit complex, inhibition by G(o) alpha, inhibited by Ca2+, and phosphorylation by protein kinases C and A.
Physiological Roles for G Protein-Regulated Adenylyl Cyclase Isoforms: Insights from Knockout and Overexpression Studies
- Rachna Sadana, C. Dessauer
- BiologyNeurosignals
- 24 October 2008
The latest on AC knockout and overexpression studies are explored to better understand the roles of G protein regulation of ACs in the brain, olfactory bulb, and heart.
Adenylyl Cyclase–A-kinase Anchoring Protein Complexes: The Next Dimension in cAMP Signaling
- C. Dessauer
- Biology, ChemistryMolecular Pharmacology
- 1 November 2009
The ability of AKAPs to assemble intricate feedback loops to control spatiotemporal aspects of cAMP signaling adds yet another dimension to the classic cAMP pathway.
Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.
- A. Bauman, J. Soughayer, John D. Scott
- Biology, ChemistryMolecules and Cells
- 15 September 2006
Isoform Selectivity of Adenylyl Cyclase Inhibitors: Characterization of Known and Novel Compounds
- Cameron S. Brand, Harrison J. Hocker, A. Gorfe, C. Cavasotto, C. Dessauer
- Chemistry, BiologyJournal of Pharmacology and Experimental…
- 1 November 2013
It is shown that compounds lacking the adenine chemical signature and targeting the ATP binding site can potentially be used to develop AC isoform–specific inhibitors, and the need to reinterpret literature using AC5/6-selective molecules SQ22,536, NKY80, and Ara-A is discussed.
International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases
- C. Dessauer, V. Watts, R. Ostrom, M. Conti, S. Dove, R. Seifert
- Biology, ChemistryPharmacological Reviews
- 1 April 2017
Understanding of the (patho)physiology of AC isoforms and the development of clinically useful drugs targeting ACs is still in its infancy, in contrast to the guanylyl cyclase field.
Creating order from chaos: cellular regulation by kinase anchoring.
- John D. Scott, C. Dessauer, K. Taskén
- BiologyAnnual Review of Pharmacology and Toxicology
- 7 January 2013
This review focuses on the pros and cons of reagents that define the biological role of kinase anchoring inside cells and discusses recent advances in the understanding of anchored second messenger signaling in the cardiovascular and immune systems.
The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain
- L. Piggott, A. Bauman, John D. Scott, C. Dessauer
- Biology, ChemistryProceedings of the National Academy of Sciences
- 16 September 2008
Disruption of Yotiao–AC interactions gives rise to a 40% increase in brain AC activity, indicating that this anchoring protein functions to directly regulate cAMP production in the brain.
Identification of a Giα Binding Site on Type V Adenylyl Cyclase*
- C. Dessauer, J. Tesmer, S. Sprang, A. Gilman
- Biology, ChemistryJournal of Biological Chemistry
- 2 October 1998
It is demonstrated that myristoylated guanosine 5′-3-O-(thio)triphosphate-Giα1 forms a stable complex with the C1 (but not the C2) domain of type V adenylyl cyclase, suggesting bidirectional regulation of activity by homologous G protein α subunits.
AKAP79 Interacts with Multiple Adenylyl Cyclase (AC) Isoforms and Scaffolds AC5 and -6 to α-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) Receptors*
- R. Efendiev, Bret K. Samelson, C. Dessauer
- Biology, ChemistryJournal of Biological Chemistry
- 15 March 2010
It is proposed that AKAP79/150 mediates protein-protein interactions that place AC5 in proximity to synaptic AMPA receptors and prevents PKA-mediated inhibition of AC activity in membranes.
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