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RUNX1/RUNX1T1 Fusion Protein

Known as: AML1-MTG8 Fusion Protein, Runt-Related Transcription Factor 1/Protein CBFA2T1 Fusion Protein, AML1/MTG8 Fusion Protein 
A fusion protein (752 aa, ~83 kDa) encoded by the RUNX1/RUNX1T1 fusion gene. This protein is comprised of the N-terminal runt domain of the runt… 
National Institutes of Health

Related topics

Related topics

3 relations
Fusion GeneRUNX1/RUNX1T1 Fusion GeneTranscription Repressor/Corepressor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Gen de fusión AML-1/ETO y mutación NPM-1A en leucemia mieloide crónica en crisis blástica mieloide
La leucemia mieloide cronica es una neoplasia mieloproliferativa de naturaleza clonal que generalmente y de manera progresiva… 
2011
2011
Sulindac Sulfide Reverses Aberrant Self-Renewal of Progenitor Cells Induced by the AML-Associated Fusion Proteins PML/RARα and PLZF/RARα
Chromosomal translocations can lead to the formation of chimeric genes encoding fusion proteins such as PML/RARα, PLZF/RARα, and… 
2009
2009
Cooperation between constitutively activated c-Kit signaling and leukemogenic transcription factors in the determination of the leukemic phenotype in murine hematopoietic stem cells.
Acute myeloid leukemia (AML) is caused by the cooperation between class I, mostly mutated receptor tyrosine kinases (RTK), and… 
2008
2008
Interlaboratory comparison of quantitative RT-PCR based detection for minimal residual disease in leukemias: a standardization approach in Japan.
Real-time quantitative polymerase chain reaction (RQ-PCR) has been accepted as integral part of the management of patients with… 
2007
2007
The Coexpression of AML1-ETO9a Isoform and AML1-ETO in Acute Myeloid Leukemia M 2 Subtype and Its Clinical Significance.
Previous studies on either animal model or clinical settings have demonstrated that the expression of AML1/ETO9a (AE9a), a… 
2003
2003
Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis
Since the 19th century, arsenic (As2O3) has been used in the treatment of chronic myelogenous leukemia (CML) characterized by the… 
2002
2002
All-trans retinoic acid as a single agent induces complete remission in a patient with acute leukemia of M2a subtype.
OBJECTIVE To present a special case with the karyotype and molecular marker of acute myeloid leukemia (AML)-M2 who was induced to… 
2002
2002
Using fluorescence‐activated cell sorting followed by fluorescence in situ hybridization to study lineage relationships: the 8;21 translocation is present in neutrophils but not monocytes in a…
Severe congenital neutropenia (Kostmann syndrome) is a disorder that presents in the neonatal period, but predisposes to leukemia… 
1998
1998
Freezing of PCR master mixture retains full amplification activity and facilitates PCR standardization for molecular diagnostics and real-time PCR
The detection of mRNA expression using reverse transcription and subsequent amplification using the polymerase chain reaction is… 
Review
1996
Review
1996
Transcriptional regulation by the t(8;21) fusion protein, AML-1/ETO.
Certain chromosomal translocations are characteristically associated with acute myeloid leukemia (AML), suggesting that… 
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