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RUNX1/RUNX1T1 Fusion Protein

Known as: AML1-MTG8 Fusion Protein, Runt-Related Transcription Factor 1/Protein CBFA2T1 Fusion Protein, AML1/MTG8 Fusion Protein 
A fusion protein (752 aa, ~83 kDa) encoded by the RUNX1/RUNX1T1 fusion gene. This protein is comprised of the N-terminal runt domain of the runt… 
National Institutes of Health

Related topics

Related topics

3 relations
Fusion GeneRUNX1/RUNX1T1 Fusion GeneTranscription Repressor/Corepressor

Papers overview

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Highly Cited
2014
Highly Cited
2014
Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling
The t(8;21)(q22;q22) rearrangement represents the most common chromosomal translocation in acute myeloid leukemia (AML). It… 
2012
2012
The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO.
AML1-ETO (AE) is a fusion product of translocation (8;21) that accounts for 40% of M2 type acute myeloid leukemia (AML). In… 
Highly Cited
2011
Highly Cited
2011
C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice
The full-length AML1-ETO (AE) fusion gene resulting from t(8;21)(q22;q22) in human acute myeloid leukemia (AML) is not sufficient… 
Highly Cited
2011
Highly Cited
2011
N-Ras(G12D) induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene.
AML1-ETO (AE) is a fusion product of t(8;21) observed in 40% French-American-British M2 type of acute myeloid leukemia (AML… 
Highly Cited
2005
Highly Cited
2005
The Vitamin D Receptor, Runx2, and the Notch Signaling Pathway Cooperate in the Transcriptional Regulation of Osteopontin*
Osteopontin (OPN), a glycosylated phosphoprotein that binds calcium, is present in bone extracellular matrix and has been… 
Highly Cited
2004
Highly Cited
2004
Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells.
Acute myeloid leukemia (AML) is characterized by the block of differentiation, deregulated apoptosis, and an increased self… 
Highly Cited
2003
Highly Cited
2003
Transcriptional regulation of the human MIP‐1α promoter by RUNX1 and MOZ
The transcription factor RUNX1 (AML-1, PEBP2αB and CBFA2) is essential for definitive haematopoiesis, and chromosomal… 
Highly Cited
2000
Highly Cited
2000
AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein.
The AML-1/ETO fusion protein, created by the (8;21) translocation in M2-type acute myelogenous leukemia (AML), is a dominant… 
Highly Cited
1999
Highly Cited
1999
ETO-2, a new member of the ETO-family of nuclear proteins
The t(8;21) is associated with 12 – 15% of acute myelogenous leukemias of the M2 subtype. The translocation results in the fusion… 
Highly Cited
1995
Highly Cited
1995
Functional domains of the t(8;21) fusion protein, AML-1/ETO.
The AML-1/ETO fusion protein is created by the (8;21) translocation, the second most frequent chromosomal abnormality associated… 
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