Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling

@article{Spirin2014SilencingAG,
  title={Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling},
  author={Pavel V. Spirin and Timofey D Lebedev and Natalia Orlova and A. S. Gornostaeva and Maria M. Prokofjeva and Natalia A Nikitenko and Sergey E Dmitriev and Anton Buzdin and Nikolay M. Borisov and Aleksandr M. Aliper and Andrew V. Garazha and Petr Rubtsov and Carol Stocking and Vladimir S. Prassolov},
  journal={Leukemia},
  year={2014},
  volume={28},
  pages={2222-2228}
}
The t(8;21)(q22;q22) rearrangement represents the most common chromosomal translocation in acute myeloid leukemia (AML). It results in a transcript encoding for the fusion protein AML1-ETO (AE) with transcription factor activity. AE is considered to be an attractive target for treating t(8;21) leukemia. However, AE expression alone is insufficient to cause transformation, and thus the potential of such therapy remains unclear. Several genes are deregulated in AML cells, including KIT that… CONTINUE READING

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References

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pathogenesis and potential therapeutic approaches

PV Spirin, F Baskaran, +3 authors EL Chernolovskaia
Front Med • 2012

C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice.

Proceedings of the National Academy of Sciences of the United States of America • 2011

[ Downregulation of activated leukemic oncogenes AML 1 - ETO and RUNX 1 ( K 83 N ) expression with RNA - interference ]

PV Spirin, F Baskaran, +3 authors EL Chernolovskaia
Mol Biol ( Mosk ) • 2010

core-binding factor subunits

G Krosl, G He, +3 authors P Jolicoeur
Neoplasia • 2010

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