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Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.
1,25-Dihydroxvitamin D3 [1,25(OH)2D3] is the hormonally active form of vitamin D. The genomic mechanism of 1,25(OH)2D3 action involves the direct binding of the 1,25(OH)2D3 activated vitamin DExpand
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1,25-Dihydroxyvitamin D3 Ameliorates Th17 Autoimmunity via Transcriptional Modulation of Interleukin-17A
ABSTRACT A new class of inflammatory CD4+ T cells that produce interleukin-17 (IL-17) (termed Th17) has been identified, which plays a critical role in numerous inflammatory conditions and autoimmuneExpand
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Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis
Emerging data indicate that neurotrophic factors and cytokines utilize similar signal transduction mechanisms. Although neurotrophic factors can protect CNS neurons against a variety of insults, theExpand
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Vitamin D: metabolism.
The biologically active metabolite of vitamin D, 1,25(OH)(2)D(3), affects mineral homeostasis and has numerous other diverse physiologic functions including effects on growth of cancer cells andExpand
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Early climbing fiber interactions with Purkinje cells in the postnatal mouse cerebellum
The time and place of initial contacts between afferent axons and their target cells are not known for most regions of the mammalian CNS. To address this issue, we have selectively visualizedExpand
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Calcium transporter 1 and epithelial calcium channel messenger ribonucleic acid are differentially regulated by 1,25 dihydroxyvitamin D3 in the intestine and kidney of mice.
We examined the expression of calcium transporter 1 (CaT1) and epithelial calcium channel (ECaC) mRNA in the duodenum and kidney of mice. Intestinal CaT1 mRNA level increased 30-fold at weaning,Expand
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Calcium buffering properties of calbindin D28k and parvalbumin in rat sensory neurones.
1. We have examined the ability of the Ca(2+)‐binding proteins (CABP) calbindin D28k and paravalbumin to modulate increases in the intracellular free Ca2+ concentration ([Ca2+]i), produced by briefExpand
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Vitamin D: beyond bone
In recent years, vitamin D has been received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries and the identification of extraskeletal effects ofExpand
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Vitamin D-dependent calcium binding proteins: chemistry, distribution, functional considerations, and molecular biology.
I. Forward One of the most important contributions to the vitamin D field has been the discovery by Wasserman and Taylor in 1966 (1) of vitamin D-dependent calcium binding protein [calbindin-D (2)].Expand
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New insights into the mechanisms of vitamin D action
The biologically active metabolite of vitamin D, 1,25‐dihydroxyvitamin D3 (1,25(OH)2D3) is a secosteroid whose genomic mechanism of action is similar to that of other steroid hormones and is mediatedExpand
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