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RUNX1/RUNX1T1 Fusion Gene

Known as: AML1/ETO FUSION GENE, ETO/AML FUSION GENE, AML/ETO Fusion Gene 
A fusion gene (~4.3 kb) that results from a chromosomal translocation t(8;21)(q22;q22) which fuses the first 5 exons of the RUNX1 gene to exon 2 of… 
National Institutes of Health

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RUNX1/RUNX1T1 Fusion ProteinTranscriptional Repression

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Identification and characterization of novel AML1-ETO fusion transcripts in pediatric t(8;21) acute myeloid leukemia: a report from the Children's Oncology Group
t(8;21)(q22;q22) results in the AML1-ETO (A1E) fusion gene and is a common cytogenetic abnormality in acute myeloid leukemia (AML… 
2002
2002
A Pediatric Case of Secondary Leukemia Associated with t(16;21)(q24;q22) Exhibiting the Chimeric AML1-MTG16 Gene
A chimeric gene, AML1-MTG16, showing high homology to AML1-MTG8, was recently identified in adult leukemic patients with the… 
2001
2001
Remission of Acute Myeloblastic Leukemia After Severe Pneumonia Treated With High-Dose Methylprednisolone
We report a case of acute myeloblastic leukemia (AML)-M2 (by French-American-British classification) with t(8;21) (q22;q22) that… 
2001
2001
The AML1/MTG8 Fusion Transcript in t(8;21) Positive AML and its Implication for the Detection of Minimal Residual Disease; Malignancy.
The reciprocal translocation t(8;21)(q22;q22) is one of the most frequent chromosomal aberrations in acute myeloblastic leukemia… 
2000
2000
The AML1/MTG8 Fusion Transcript in t(8;21) Positive AML and its Implication for the Detection of Minimal Residual Disease
The reciprocal translocation t(8;21)(q22;q22) is one of the most frequent chromosomal aberrations in acute myeloblastic leukemia… 
1999
1999
Complex translocation (6;21;8), a variant of t(8;21), with trisomy 4 in a patient with acute myelogenous leukemia (M2).
Review
1998
Review
1998
Molecular monitoring of minimal residual disease in acute myeloblastic leukemia with t(8;21) by RT-PCR.
The t(8;21) is one of the most common translocations in acute myeloid leukaemia (AML) occurring in approximately 20% of adult and… 
1998
1998
Tumourigenicity of MTG8, a leukaemia‐related gene, in concert with v‐Ha‐ras gene in BALB/3T3 cells
The MTG8 (ETO) gene has been identified as the translocation partner of AML1 (PEBP2αB or CBFα2) gene in the AML1/MTG8 (ETO) fused… 
1997
1997
Expression of AML1/MTG8 transcripts in clonogenic cells grown from bone marrow of patients in remission of acute myeloid leukaemia with t(8;21)
Patients in long‐term remission of acute myeloid leukaemia (AML) M2 with t(8;21) after chemotherapy, with or without bone marrow… 
1995
1995
Ribozymes cleave the AML1/MTG8 fusion transcript and inhibit proliferation of leukemic cells with t(8;21).
The AML1/MTG8 fusion gene is thought to have a critical role in the leukemogenesis of AML with t(8;21)(q22;q22). To specifically… 
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