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RU 58841

Known as: RU-58841, RU58841 
 
National Institutes of Health

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ImidazolesNitriles

Papers overview

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2014
2014
Alternative synthesis of the anti-baldness compound RU58841
RU58841 is active against baldness and is commercially available. The previously reported synthesis uses phosgene, three discrete… Expand
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Highly Cited
1998
Highly Cited
1998
Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells.
Although hormone therapy with antiandrogens has been widely used for the treatment of prostate cancer, some antiandrogens may act… Expand
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1998
1998
Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques
The effect of androgen receptor transcriptional activation by RU58841, a nonsteroidal anti-androgen, was studied in the human… Expand
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1997
1997
Effects of topical antiandrogen and 5-alpha-reductase inhibitors on sebaceous glands in male fuzzy rats.
The fuzzy rat, a genetic mutant between hairless and hairy albino rats, expresses androgen-dependent hypersecretion of sebum and… Expand
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1997
1997
Dose-dependent and long term effects of RU58841 (androgen receptor blocker) on hair growth in the bald stumptailed Macaque.
 
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1997
1997
A controlled study of the effects of RU58841, a non‐steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone‐conditioned nude mice
Summary Human hair growth can be monitored for several months after the transplantation of scalp samples from men with androgen… Expand
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Highly Cited
1997
Highly Cited
1997
Importance of sebaceous glands in cutaneous penetration of an antiandrogen: target effect of liposomes.
The significance of the sebaceous gland pathway in the cutaneous permeation of an antiandrogen, 4-[3-(4-hydroxybutyl)-4,4… Expand
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1995
1995
Local Inhibition of Sebaceous Gland Growth by Topically Applied RU 58841
The biological activity of a series of nonsteroidal, pure androgen receptor inhibitors was compared using the Syrian hamster ear… Expand
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1995
1995
Follicular regrowth with 5 α-reductase inhibitor (finasteride) or androgen receptor blocker (RU58841) in the bald scalp of the stumptailed macaque.
 
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1994
1994
RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism
A new topically active non-steroidal antiandrogen, RU 58841 has been synthesized. It displays high affinity for the hamster… Expand
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