Local Inhibition of Sebaceous Gland Growth by Topically Applied RU 58841

@article{Matias1995LocalIO,
  title={Local Inhibition of Sebaceous Gland Growth by Topically Applied RU 58841},
  author={J. Matias and M. Gaillard},
  journal={Annals of the New York Academy of Sciences},
  year={1995},
  volume={761}
}
The biological activity of a series of nonsteroidal, pure androgen receptor inhibitors was compared using the Syrian hamster ear skin sebaceous gland model. RU 58841, RU 56187, RU 38882 and cyproterone acetate were applied topically for 4 weeks on the ventral ear pinna of sexually mature male Syrian hamsters. Their order of efficacy was as follows: RU 58841 > RU 56187 > RU 38882 > cyproterone acetate. Maximal reduction of 60% in the size of the sebaceous glands was observed in hamsters treated… Expand
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