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Comparison of Diluted Bitumen (Dilbit) and Conventional Crude Oil Toxicity to Developing Zebrafish.
- D. Philibert, Clara P Philibert, Carlie R. Lewis, K. Tierney
- ChemistryEnvironmental science & technology
- 24 May 2016
The results suggest that the toxicity of dilbit to a model fish is less than or similar to that of conventional crudes.
RU 38486: An Original Multifaceted Antihormone in Vivo
- D. Philibert
- 31 January 1984
17α-Alkynyl-11β,17-dihydroxyandrostane derivatives : A new class of potent glucocorticoids.
History and perspectives of antiprogestins from the chemist's point of view.
The literature has been searched for available data on abortive activities, and some as yet unpublished results on RU compounds have been included and it appears that a number of compounds are both more active than RU486 on a dose basis in animal studies and more dissociated in relation to a possible antiglucocorticoid activity.
The pharmacological profile of a novel norpregnance progestin (trimegestone).
- D. Philibert, F. Bouchoux, M. Degryse, D. Lecaque, F. Petit, M. Gaillard
- Biology, MedicineGynecological endocrinology : the official…
Results show trimegestone to have a favorable pharmacological profile with potent progestomimetic activity, and to be not associated with any unwanted pharmacological effects.
17 alpha-alkynyl-11 beta, 17-dihydroxyandrostane derivatives : a new class of potent glucocorticoids.
- G. Teutsch, G. Costerousse, R. Deraedt, J. Benzoni, M. Fortin, D. Philibert
- Biology, ChemistrySteroids
Replacement of the characteristic dihydroxyacetone side chain of corticoids by a 17 alpha-alkynyl-17 beta-hydroxy moiety is found to be favorable for high local anti-inflammatory activity with reduced systemic effects and may be considered as pure glucocorticoids.
Pharmacological Profile of RU 486 in Animals
According to the bioassay used, RU 486 administered orally at doses between 3 and 20 mg/kg completely inhibits the effect of exogenous progesterone on the endometrial proliferation in rabbits, on the volume density of uterine gland cell mitochondria, and on the maintenance of pregnancy in ovariectomized rats.
Progesterone and RU486: opposing effects on human sperm.
- J. Yang, C. Serres, D. Philibert, P. Robel, E. Baulieu, P. Jouannet
- Biology, MedicineProceedings of the National Academy of Sciences…
- 18 January 1994
The progesterone antagonist RU486 (mifepristone) induced an immediate and transient, dose-dependent decrease of intracellular free calcium and a drop in the values of sperm movement parameters related to hyperactivation, and RU486 counteracted the effects of progester one on calcium influx, lateral sperm head displacement, and the acrosome reaction.
Non-steroidal antiandrogens: Synthesis and biological profile of high-affinity ligands for the androgen receptor