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Background Overexpression of the MUC5B protein is associated with idiopathic pulmonary fibrosis (IPF), but little information is… Expand Typical features of dyskeratosis congenita (DC) resulting from excessive telomere shortening include bone marrow failure (BMF… Expand Heterozygous mutations in four telomere-related genes have been linked to pulmonary fibrosis, but little is known about… Expand RATIONALE
Up to 20% of cases of idiopathic interstitial pneumonia cluster in families, comprising the syndrome of familial… Expand Pulmonary fibrosis is a fatal disease with progressive loss of respiratory function. Defective telomere maintenance leading to… Expand Hoyeraal-Hreidarsson syndrome (HHS) is a severe form of Dyskeratosis congenita characterized by developmental defects, bone… Expand A helicase is required to preserve genome stability in plants, which is likely due to its role in destabilizing various types of… Expand Significance Telomeres protect the ends of eukaryotic chromosomes. Telomeres shorten with age and serve as a biological clock… Expand Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the… Expand Little is known about the genes that regulate telomere length diversity between mammalian species. A candidate gene locus was… Expand