RTEL1 gene

RATIONALE Up to 20% of cases of idiopathic interstitial pneumonia cluster in families, comprising the syndrome of familial… (More)

Pulmonary fibrosis is a fatal disease with progressive loss of respiratory function. Defective telomere maintenance leading to… (More)

Hoyeraal-Hreidarsson syndrome (HH) is a clinically severe variant of dyskeratosis congenita (DC), characterized by cerebellar… (More)

For decades, it has been recognised that cases of pulmonary fibrosis cluster in families. While previous studies have implicated… (More)

Regulator of telomere elongation helicase 1 (RTEL1) is critical for genome stability and tumor avoidance. Many studies have… (More)

Telomeres repress the DNA damage response at the natural chromosome ends to prevent cell-cycle arrest and maintain genome… (More)

Common variants of multiple genes play a role in glioma onset. However, research related to astrocytoma, the most common primary… (More)

Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the… (More)

Regulator of telomere length (RTEL) is a DNA helicase-like protein that has recently been demonstrated to be required for the… (More)

Little is known about the genes that regulate telomere length diversity between mammalian species. A candidate gene locus was… (More)