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RTEL1 gene

Known as: CHROMOSOME 20 OPEN READING FRAME 41, RTEL1, TELOMERE LENGTH REGULATOR 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Genes
TNFRSF6B geneTNFRSF6B wt Allele

Papers overview

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Highly Cited
2016
Highly Cited
2016
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive
Heterozygous mutations in four telomere-related genes have been linked to pulmonary fibrosis, but little is known about… Expand
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Highly Cited
2015
Highly Cited
2015
Rare variants in RTEL1 are associated with familial interstitial pneumonia.
RATIONALE Up to 20% of cases of idiopathic interstitial pneumonia cluster in families, comprising the syndrome of familial… Expand
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Highly Cited
2015
Highly Cited
2015
Heterozygous RTEL1 mutations are associated with familial pulmonary fibrosis
Pulmonary fibrosis is a fatal disease with progressive loss of respiratory function. Defective telomere maintenance leading to… Expand
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2015
2015
Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA
Hoyeraal-Hreidarsson syndrome (HHS) is a severe form of Dyskeratosis congenita characterized by developmental defects, bone… Expand
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2014
2014
The Arabidopsis thaliana Homolog of the Helicase RTEL1 Plays Multiple Roles in Preserving Genome Stability[C][W]
A helicase is required to preserve genome stability in plants, which is likely due to its role in destabilizing various types of… Expand
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Highly Cited
2013
Highly Cited
2013
Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal–Hreidarsson syndrome
Significance Telomeres protect the ends of eukaryotic chromosomes. Telomeres shorten with age and serve as a biological clock… Expand
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2013
2013
RTEL1 and TERT polymorphisms are associated with astrocytoma risk in the Chinese Han population
Common variants of multiple genes play a role in glioma onset. However, research related to astrocytoma, the most common primary… Expand
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Highly Cited
2012
Highly Cited
2012
Genome-wide association study of glioma and meta-analysis
Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the… Expand
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2011
2011
Generation of a mouse model for studying the role of upregulated RTEL1 activity in tumorigenesis
Regulator of telomere length 1 (RTEL1) is a DNA helicase protein that has been demonstrated to be required for the maintenance of… Expand
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Highly Cited
2004
Highly Cited
2004
Regulation of Murine Telomere Length by Rtel An Essential Gene Encoding a Helicase-like Protein
Little is known about the genes that regulate telomere length diversity between mammalian species. A candidate gene locus was… Expand
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