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Playing the end game: DNA double-strand break repair pathway choice.
RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
Double-strand break repair: 53BP1 comes into focus
A model is emerging in which 53BP1 recruitment requires the direct recognition of a DSB-specific histone code and its influence on pathway choice is mediated by mutual antagonism with breast cancer 1 (BRCA1).
Components of the Ku‐dependent non‐homologous end‐joining pathway are involved in telomeric length maintenance and telomeric silencing
It is demonstrated that SIR2, SIR3 and SIR4, three genes shown previously to function in TPE, are essential for Ku‐dependent DSB repair, and RAD50, MRE11 and XRS2 function both in Ku‐ dependent DNA D SB repair and in telomeric length maintenance, although they have no major effects on TPE.
HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis.
Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance.
The identification and characterisation of YKU80, the gene for the Saccharomyces cerevisiae Ku80 homologue, are described and it is reported that yku80 mutant yeasts display dramatic telomeric shortening, suggesting that, in addition to recognising DNA damage, Ku also binds to naturally occurring chromosomal ends.
Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double‐strand break repair and serves as a barrier to error‐prone DNA repair pathways.
It is shown that the simple inactivation of the Saccharomyces cerevisiae Ku70 homologue (Yku70p), does not lead to increased radiosensitivity, and studies suggest that Yku70 promotes genomic stability both by promoting accurate DNA repair and by serving as a barrier to error‐prone repair processes.
Poly(ADP-ribose)–Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1
A chromatin-remodeling enzyme, ALC1 (Amplified in Liver Cancer 1, also known as CHD1L), is identified that interacts with poly(ADP-ribose) and catalyzes PARP1-stimulated nucleosome sliding and provides new insights into the mechanisms by which poly(adenosine 5′-diphosphate (ADP)–riboses) regulates DNA repair.
Caenorhabditis elegans HUS-1 Is a DNA Damage Checkpoint Protein Required for Genome Stability and EGL-1-Mediated Apoptosis
REV7 counteracts DNA double-strand break resection and affects PARP inhibition
This work shows that loss of REV7 in mouse and human cell lines re-establishes CTIP-dependent end resection of DSBs in BRCA1-deficient cells, leading to HR restoration and PARP inhibitor resistance, which is reversed by ATM kinase inhibition.