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RS 8359

Known as: RS-8359 
National Institutes of Health

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2 relations

Broader (2)

NitrilesPyrimidines

Papers overview

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2006
2006
Species differences in enantioselective 2‐oxidations of RS‐8359, a selective and reversible MAO‐A inhibitor, and cinchona alkaloids by aldehyde oxidase
The 2‐oxidation activity on the pyrimidine ring of RS‐8359, a MAO‐A inhibitor, is the major metabolic pathway catalysed by… 
2006
2006
Rat strain differences in stereospecific 2‐oxidation of RS‐8359, a reversible and selective MAO‐A inhibitor, by aldehyde oxidase
Aldehyde oxidase catalysed 2‐oxidation activity of the (S)‐enantiomer of RS‐8359, a selective and reversible monoamine oxidase A… 
2005
2005
Stereoselective pharmacokinetics of RS-8359, a selective and reversible MAO-A inhibitor, by species-dependent drug-metabolizing enzymes.
RS-8359, (+/-)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]pyrimidine selectively and reversibly inhibits monoamine… 
2005
2005
Stereospecific oxidation of the (S)-enantiomer of RS-8359, a selective and reversible monoamine oxidase A (MAO-A) inhibitor, by aldehyde oxidase
In a previous paper by the authors on RS-8359, a new selective and reversible monoamine oxidase A (MAO-A) inhibitor, it was… 
2005
2005
Changes in monoamine levels in mouse brain elicited by forced-swimming stress, and the protective effect of a new monoamine oxidase inhibitor, RS-8359
As a stress model, a forced swimming test was applied to mice; and a typical behavioral change, an immobile posture, was… 
1999
1999
Stereoselective pharmacokinetics of RS-8359, a selective and reversible inhibitor of A-type monoamine oxidase, in rats, mice, dogs, and monkeys.
RS-8359, (+/-)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-py rimidine, inhibits, selectively and reversely, A-type… 
1997
1997
The effects of RS‐8359 on cardiovascular function in healthy subjects and depressed patients
The potential liability of RS-8359 for the ‘cheese’ effect that is characteristic of the classical monoamine oxidase inhibitors… 
1997
1997
The pharmacokinetic profile of RS‐8359
RS-8359 is very rapidly absorbed, metabolized and distributed following oral dosing, with significant concentrations of both… 
Highly Cited
1991
Highly Cited
1991
Monoamine oxidase inhibitors prevent striatal neuronal necrosis induced by transient forebrain ischemia
1989
1989
Comparative Studies of the Effects of RS‐8359 and Safrazine on Monoamine Oxidase In‐vitro and In‐vivo in Mouse Brain
Abstract— The effect of RS‐8359, (±)‐4‐(4‐cyanophenyl)amino‐6,7‐dihydro‐7‐hydroxy‐5H‐cyclopenta[d]‐pyrimidine on monoamine… 
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