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RS 8359
Known as:
RS-8359
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Nitriles
Pyrimidines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Species differences in enantioselective 2‐oxidations of RS‐8359, a selective and reversible MAO‐A inhibitor, and cinchona alkaloids by aldehyde oxidase
K. Itoh
,
M. Yamamura
,
W. Takasaki
,
Takamitsu Sasaki
,
A. Masubuchi
,
Yorihisa Tanaka
Biopharmaceutics & drug disposition
2006
Corpus ID: 5846508
The 2‐oxidation activity on the pyrimidine ring of RS‐8359, a MAO‐A inhibitor, is the major metabolic pathway catalysed by…
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2006
2006
Rat strain differences in stereospecific 2‐oxidation of RS‐8359, a reversible and selective MAO‐A inhibitor, by aldehyde oxidase
Takamitsu Sasaki
,
A. Masubuchi
,
+5 authors
Yorihisa Tanaka
Biopharmaceutics & drug disposition
2006
Corpus ID: 27327296
Aldehyde oxidase catalysed 2‐oxidation activity of the (S)‐enantiomer of RS‐8359, a selective and reversible monoamine oxidase A…
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2005
2005
Stereoselective pharmacokinetics of RS-8359, a selective and reversible MAO-A inhibitor, by species-dependent drug-metabolizing enzymes.
W. Takasaki
,
M. Yamamura
,
+4 authors
Yorihisa Tanaka
Chirality
2005
Corpus ID: 35716246
RS-8359, (+/-)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]pyrimidine selectively and reversibly inhibits monoamine…
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2005
2005
Stereospecific oxidation of the (S)-enantiomer of RS-8359, a selective and reversible monoamine oxidase A (MAO-A) inhibitor, by aldehyde oxidase
K. Itoh
,
M. Yamamura
,
+4 authors
Y. Tanaka
Xenobiotica; the fate of foreign compounds in…
2005
Corpus ID: 37531405
In a previous paper by the authors on RS-8359, a new selective and reversible monoamine oxidase A (MAO-A) inhibitor, it was…
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2005
2005
Changes in monoamine levels in mouse brain elicited by forced-swimming stress, and the protective effect of a new monoamine oxidase inhibitor, RS-8359
H. Miura
,
M. Naoi
,
D. Nakahara
,
T. Ohta
,
T. Nagatsu
Journal of Neural Transmission / General Section…
2005
Corpus ID: 5644103
As a stress model, a forced swimming test was applied to mice; and a typical behavioral change, an immobile posture, was…
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1999
1999
Stereoselective pharmacokinetics of RS-8359, a selective and reversible inhibitor of A-type monoamine oxidase, in rats, mice, dogs, and monkeys.
W. Takasaki
,
M. Yamamura
,
+4 authors
Y. Tanaka
Biological and Pharmaceutical Bulletin
1999
Corpus ID: 36317288
RS-8359, (+/-)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-py rimidine, inhibits, selectively and reversely, A-type…
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1997
1997
The effects of RS‐8359 on cardiovascular function in healthy subjects and depressed patients
Astrid Plenker
,
K. Püchler
,
H. Volz
International Clinical Psychopharmacology
1997
Corpus ID: 20802379
The potential liability of RS-8359 for the ‘cheese’ effect that is characteristic of the classical monoamine oxidase inhibitors…
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1997
1997
The pharmacokinetic profile of RS‐8359
K. Püchler
,
K. Sasahara
,
A. Plenker
,
T. Nitanai
,
P. Witte
International Clinical Psychopharmacology
1997
Corpus ID: 1454735
RS-8359 is very rapidly absorbed, metabolized and distributed following oral dosing, with significant concentrations of both…
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Highly Cited
1991
Highly Cited
1991
Monoamine oxidase inhibitors prevent striatal neuronal necrosis induced by transient forebrain ischemia
Y. Matsui
,
Y. Kumagae
Neuroscience Letters
1991
Corpus ID: 40085665
1989
1989
Comparative Studies of the Effects of RS‐8359 and Safrazine on Monoamine Oxidase In‐vitro and In‐vivo in Mouse Brain
T. Yokoyama
,
Toshio Karube
,
N. Iwata
The Journal of pharmacy and pharmacology
1989
Corpus ID: 9274798
Abstract— The effect of RS‐8359, (±)‐4‐(4‐cyanophenyl)amino‐6,7‐dihydro‐7‐hydroxy‐5H‐cyclopenta[d]‐pyrimidine on monoamine…
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