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RRx-001

Known as: Radiosensitizer RRx-001 
A dinitroazetidine derivative with potential radiosensitizing activity. Upon administration, RRx-001 is able to dilate blood vessels, thereby… 
National Institutes of Health

Related topics

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2 relations

Broader (2)

AzetidinesNitro Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Two Case Reports of Resensitization to Previous Chemotherapy with the Novel Hypoxia-Activated Hypomethylating Anticancer Agent RRx-001 in Metastatic Colorectal Cancer Patients
The development of chemoresistance is a persistent problem during the treatment of cancer. Although reversion or modification of… 
Review
2006
Review
2006
Design of hypoxia-targeting drugs as new cancer chemotherapeutics.
The tumor microenvironment is now recognized as a major factor that influences not only the response to conventional anti-cancer… 
1997
1997
Design, synthesis, and biological activity of anti-angiogenic hypoxic cell radiosensitizer haloacetylcarbamoyl-2-nitroimidazoles.
1992
1992
Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908.
Highly Cited
1986
Highly Cited
1986
The differential cytotoxicity of RSU 1069: cell survival studies indicating interaction with DNA as a possible mode of action.
The hypoxic cell radiosensitizer RSU 1069 (1-(2-nitro-1-imidazolyl)-3-(1-aziridinyl)-2-propanol) shows, on a concentration basis… 
Highly Cited
1984
Highly Cited
1984
Initial report of the phase I trial of the hypoxic cell radiosensitizer SR-2508.
1983
1983
Synthesis and in vivo studies of the radiosensitizer 4-[82Br]bromomisonidazole.
1982
1982
In vivo testing of a 2-nitroimidazole radiosensitizer (Ro 03-8799) using repeated administration.
1976
1976
The response of a transplantable tumor to fractionated irradiation. 1. X rays and the hypoxic cell radiosensitizer Ro-07-0582.
The response of transplantable mammary carcinoma in CBA mice to single doses and two or five fractions of x rays, with and… 
1976
1976
The response of a transplantable tumor to fractionated irradiation. II. Fast neutrons.
A transplantable murine carcinoma has been used to compare the relative effect of single doses, 2 and 5 fractions of x rays, and… 
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