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Upon activation of the ERK and p38 MAPK pathways, the MSK1/2-mediated nucleosomal response, including H3 phosphorylation at… Expand Neurotrophins are growth factors that are important in neuronal development and survival as well as synapse formation and… Expand MicroRNAs are involved in cancer pathogenesis and act as tumor suppressors or oncogenes. It has been recently reported that miR… Expand The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated protein kinases. Here we found that… Expand MSK1 (mitogen- and stress-activated kinase 1) is a dual kinase domain protein that acts downstream of the ERK1/2 (extracellular… Expand Mitogen and stress-activated kinase-1 (MSK1) is a serine/threonine protein kinase that is activated by either p38 or p42ERK MAPKs… Expand OBJECTIVE
Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation… Expand Stimulation of the Ras-mitogen-activated protein kinase (MAPK) pathway by growth factors, phorbol esters, and oncoproteins… Expand N-terminal tail phosphorylation of histone H3 plays an important role in gene expression, chromatin remodeling, and chromosome… Expand A novel protein kinase whose activity can be stimulated by mitogen in vivo was cloned and characterized. The cDNA of this gene… Expand