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ROR1 gene

Known as: Receptor Tyrosine Kinase-Like Orphan Receptor 1 Gene, NEUROTROPHIC TYROSINE KINASE, RECEPTOR-RELATED 1, ROR1 
This gene is thought to play a role in skeletal and cardiac development, but an exact function has yet to be determined.
National Institutes of Health

Related topics

Related topics

6 relations
Ligand BindingPhosphorylationROR1 protein, humanReceptor Signaling
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Papers overview

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2019
2019
ROR1-CAVIN3 interaction required for caveolae-dependent endocytosis and pro-survival signaling in lung adenocarcinoma
The receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a transcriptional target of the lineage-survival oncogene NKX2–1… Expand
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2016
2016
ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1
The receptor tyrosine kinase-like orphan receptor 1 (ROR1) sustains prosurvival signalling directly downstream of the lineage… Expand
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2016
2016
Receptor tyrosine kinase‐like orphan receptor 1, a target of NKX2‐1/TTF‐1 lineage‐survival oncogene, inhibits apoptosis signal‐regulating kinase 1‐mediated pro‐apoptotic signaling in lung…
We previously identified receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a transcriptional target of the NKX2-1/TTF-1… Expand
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2015
2015
Spontaneous Immunity Against the Receptor Tyrosine Kinase ROR1 in Patients with Chronic Lymphocytic Leukemia
BACKGROUND ROR1 is a receptor tyrosine kinase expressed in chronic lymphocytic leukemia (CLL) and several other malignancies but… Expand
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Highly Cited
2014
Highly Cited
2014
Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy.
Although initially responsive to chemotherapy, many patients with ovarian cancer subsequently develop relapsed and potentially… Expand
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Highly Cited
2012
Highly Cited
2012
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.
We and others previously identified NKX2-1, also known as TITF1 and TTF-1, as a lineage-survival oncogene in lung adenocarcinomas… Expand
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2012
2012
Abstract LB-17: NKX2-1/TITF1/TTF-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
Emerging evidence, though currently sparse, suggests that “lineage-specific transcription factors” with developmental roles in… Expand
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2009
2009
Nuclear localization of orphan receptor protein kinase (Ror1) is mediated through the juxtamembrane domain
BackgroundSeveral receptor tyrosine kinases (RTKs) such as EGFR, FGFR, TRK, and VEGFR are capable of localizing in the cell… Expand
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2005
2005
Comparative genomics on ROR1 and ROR2 orthologs.
Transmembrane proteins with extracellular Frizzled domain, such as ROR1, ROR2, MUSK, MFRP, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6… Expand
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Highly Cited
2001
Highly Cited
2001
Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development
In mammals, the Ror-family receptor tyrosine kinases consist of two structurally related proteins, Ror1 and Ror2, characterized… Expand
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